A case of pachydermoperiostosis presented to us in rheumatology clinic with complaints of pain and swelling in knee joints unresponsive to treatment, characteristic facial features, grade four clubbing of nails and broadening of distal parts of extremities. He also complained of fatiguability which was due to anemia. The natural history of the disease was reviewed and investigated.

Dear Editor, Pachydermoperiostosis (PDP; Online Mendelian Inheritance in Man #614441) is a rare hereditary disease characterized by distinctive digital clubbing, periostosis and pachydermia. Patients with PDP harbor homozygous mutations in the solute carrier organic anion transporter family member 2A1 gene (SLCO2A1) or the 15-hydroxyprostaglandin dehydrogenase gene (HPGD), resulting in elevated...

Pachydermoperiostosis is a very rare osteoarthrodermopathic disorder whose clinical and radiographic presentations may mimic those of acromegaly. In the evaluation of patients with acromegaloid appearances, pachydermoperiostosis should be considered as a differential diagnosis. In this article, we report a 17-year-old boy who presented with 2-year history of acral enlargement and facial appeara...

Touraine-Soulente-Golé Syndrome (TSG) or pachydermoperiostosis is a rare disorder characterized by pachydermia, periostosis & digital clubbing. Herein, we report a case of a 27 year old male, with the looks of a 47 year old. He presented with excessive wrinkling on his face since past 8 years. TSG syndrome was suspected and examined by histopathological, endocrinological and radiological studie...

Sir, Read with interest the article, prevalence of colonic polyp and its predictors in patients with acromegaly. [1] Pachydermoperiostosis (PDP) or primary hypertrophic osteoarthropathy is a rare disorder that is characterized by digital clubbing and subperiosteal new bone formation associated with pain, polyarthiritis, cutis verticis gyrata, seborrhea, and hyperhidrosis. It is important to the...

A paquidermoperiostose é uma síndrome caracterizada por acometimento cutâneo e ósseo, e em alguns casos ocorre comprometimento palpebral leve. É uma síndrome rara, idiopática ou hereditária, com provável herança autossômica dominante de penetrância variável. Descreve-se o caso de um paciente com ptose grave por paquidermoperiostose elucidando sua fisiopatologia e conduta cirúrgica aplicada. Des...

1 Medical Student at Universidade Federal de Santa Maria – UFSM, Santa Maria, RS 2 Specialist in Rheumatology; Assistant Professor of the Discipline of Rheumatology of the Department of Internal Medicine of UFSM, Santa Maria, RS 3 M.Sc. Degree in Internal Medicine at Universidade Federal do Rio Grande do Sul – UFRGS; and Assistant Professor of the Discipline of Rheumatology of the Department of...

Acromegaly is a neuroendocrine disease with diverse clinical manifestations that develop over long period. In the process of examining patient, it may be necessary to conduct differential diagnosis acromegaly various syndromes and conditions, including such rare as pachydermoperiostosis. Features presentation are given in description case from our practice.