the biological effects of omega-3 and omega-6 fatty acids are determined by their mutual interactions. this interaction extremely affects various functions. lower consumption of omega-3 during gestation leads to various disorders, even in hearing. we aimed to assess the effect of low omega-3/omega-6 ratios on auditory nerve conduction. in this experimental study, the auditory brainstem response...

objective(s) gastric ulceration is induced by various forms of stress like surgery, ischemia and trauma. the female sex has more resistance to stress and the gastrointestinal lesions happen fewer than male sex. the purpose of this study was to evaluate the role of estradiol and progesterone on the gastric acid and pepsin levels following traumatic brain injury (tbi) induction. materials and met...

A P4-transversal of a graph G is a set of vertices T which meets every P4 of G. A P4transversal T is called stable if there are no edges in the subgraph of G induced by T . It has been previously shown by Hoàng and Le that it is NP -complete to decide whether a comparability (and hence perfect) graph G has a stable P4-transversal. In the following we show that the problem is NP -complete for ch...

Call a graph G k-stable (with respect to some graph H) if, deleting any k edges of G, the remaining graph still contains H as a subgraph. For a fixed H, the minimum number of edges in a k-stable graph is denoted by S(k). We prove general bounds on S(k) and compute the exact value of the function S(k) for H = P4. The main result can be applied to extremal k-edge-hamiltonian hypergraphs.

We investigated the antitumorogenic effects of progesterone (P4) in a human neuroblastoma (SK-N-AS) cell line in vitro and in a mouse xenograft model of neuroblastoma. The safety of P4 was tested in rat primary cortical neurons and human foreskin fibroblasts (HFF-1). At high doses, P4 significantly (P < 0.05) decreased SK-N-AS cell viability in vitro, and this effect was not blocked either by 5...

Let G be a simple graph and L = L(G) the Laplacian matrix of G. G is called L-integral if all its Laplacian eigenvalues are integer numbers. It is known that every cograph, a graph free of P4, is L-integral. The class of P4-sparse graphs and the class of P4-extendible graphs contain the cographs. It seems natural to investigate if the graphs in these classes are still L-integral. In this paper ...

Well-timed progression of primordial folliculogenesis is essential for mammalian female fertility. Progesterone (P4) inhibits primordial follicle formation under physiological conditions; however, P4 receptor that mediates this effect and its underlying mechanisms are unclear. In this study, we used an in vitro organ culture system to show that progesterone receptor membrane component 1 (PGRMC1...

A novel colorimetric probe (P4) for the selective differential detection of DFP (a Sarin and Soman mimic) and DCNP (a Tabun mimic) was prepared. Probe P4 contains three reactive sites; i.e. (i) a nucleophilic phenol group able to undergo phosphorylation with nerve gases, (ii) a carbonyl group as a reactive site for cyanide; and (iii) a triisopropylsilyl (TIPS) protecting group that is known to ...

Oocyte maturation and embryo development are controlled by intra-ovarian factors such as steroid hormones. Progesterone (P4) exists in the follicular fluid that contributes to normal mammalian ovarian function and has several critical functions during embryo development and implantation, including endometrial receptivity, embryonic survival during gestation and transformation of the endometrial...

The aim of this study was to examine whether active metabolites of phytoestrogens (equol and para-ethyl-phenol) inhibit sensitivity of bovine corpus luteum (CL) to luteinizing hormone (LH) and to auto/paracrine luteotropic factors (prostaglandin E2-PGE2 and prostaglandin F(2alpha)-PGF(2alpha)), and whether they influence pulsatile progesterone (P4) secretion by the bovine CL. In in vivo experim...