Antibodies directed against the autoantigen p26 were detected in sera from 32 patients with acute Epstein-Barr virus (EBV) infection and clinical symptoms of infectious mononucleosis. P26 has now been identified as the enzyme manganese superoxide dismutase (MnSOD) by comparison of the NH2-terminal amino acid sequence. Antibodies against MnSOD belong to the immunoglobulin class M. They are not d...

No município de São Carlos, o importante manancial superficial do Rio Monjolinho tem as cabeceiras localizadas na região periurbana, com zona urbana consolidada, industrial e rural. Os aquíferos freáticos da sub-bacia, possuem importância dinâmica hidrológica, entretanto ainda sem investigação quanto à sua qualidade hidroquímica. Este trabalho buscou conhecer os impactos gerados pelas atividade...

Administration of 2-acetylaminofluorene to rats for 12 weeks induces hyperplastic nodules (HPNs) and later well-differentiated hepatocellular carcinomas (HCCs) in the liver. Total cellular proteins from normal liver, HPN, and HCC were analyzed by two-dimensional gel electrophoresis with a high resolution. Several hundred polypeptides were well resolved as seen by Coomassie blue staining, formin...

We analyzed the performance of a single-band Western blot (WB) test using recombinant p26 (rp26) capsid protein of equine infectious anemia virus. According to the results obtained, the rp26 WB test is a reliable confirmatory diagnostic tool to be used as a complementary test after an enzyme-linked immunosorbent assay or agar gel immunodiffusion test yielding doubtful results.

Natural peptide antibiotics are part of host innate immunity against a wide range of microbes, including some viruses. Synthetic peptides modeled after natural peptide antibiotics interfere with microbial membranes and are termed peptidyl membrane-interactive molecules (peptidyl-MIM [Demegen Inc, Pittsburgh, Pa.]). Sixteen peptidyl-MIM candidates were tested for activity against feline immunode...

Both cellular and viral proteins can undergo phase separation form membraneless compartments that concentrate biomolecules. The p26 movement protein from single-stranded, positive-sense Pea enation mosaic virus 2 (PEMV2) separates into a dense in nucleoli where related orthologues must interact with fibrillarin (Fib2) as pre-requisite for systemic movement. Using vitro assays, ribonucleoprotein...

The meaning of alternative biotests is described and discussed. The paper also deals with the possible application of the developmental studies of the sea Artemia franciscana nauplinus. Five-day biotests including the validation criteria are described. The possibilities of the biotests are very wide. Additionally to the standard applications in ecotoxicology, there is a possibility of modelling...

23 p23 UPDATE informs you of changes in clinical practice. This week: smoking prevalence p26 PrAcTicAl ProcEDUrEs illustrates procedures. This week: assessing consciousness p28 gUiDED lEArNiNg includes online cPD. This week: surgery and haemophilia p30 DEVEloPmENT shows how nurses are developing practice. This week: delegating consent-taking p32 rEsEArcH presents research papers. This week: pat...

23 p23 UPDATE informs you of changes in clinical practice. This week: contraception p26 PrAcTicAl PrOcEDUrEs illustrates procedures. This week: removing an indwelling catheter p28 gUiDED lEArNiNg includes online cPD. This week: law on advance decisions p30 DEVElOPmENT shows how nurses are developing practice. This week: evaluating telemedicine p32 rEsEArcH presents research papers. This week: s...