نتایج جستجو برای: p1621 23

تعداد نتایج: 187379  

Journal: :Genetics and molecular research : GMR 2014
Y K Kang M C Zhang

The aim of this study was to determine the effect of IL-23 on the activity and proliferation of osteoclasts (OC) in co-culture with osteoblasts (OB). OB and OC were individually separated from the skull and femoral bone of a SD rat. OB-OC co-culture with IL-23 added was designed as the experimental group, while the OB-OC co-culture without IL-23 was the control group. In the experimental group,...

2013
Juan-Hua Quan Wei Zhou Guang-Ho Cha In-Wook Choi Dae-Whan Shin Young-Ha Lee

IL-23 and IL-12 are structurally similar and critical for the generation of efficient cellular immune responses. Toxoplasma gondii induces a strong cell-mediated immune response. However, little is known about IL-23 secretion profiles in T. gondii-infected immune cells in connection with IL-12. We compared the patterns of IL-23 and IL-12 production by THP-1 human monocytic cells in response to ...

Journal: :European journal of immunology 2009
Benjamin M Segal

IL-23 plays a critical role in EAE induced by the active immunization of C57BL/6 mice with an immunodominant epitope of myelin oligodendrocyte glycoprotein (MOG(35-55)). It was initially assumed that the pathogenic effects of IL-23 were directly related to the generation, expansion and/or stabilization of autoreactive CD4(+) Th17 cells. However, a number of recent studies have uncovered discrep...

2013
Hui Shen Wei Zhang Clara Abraham Judy H. Cho

The interleukin-23 (IL-23) pathway plays a critical role in the pathogenesis of multiple chronic inflammatory disorders, however, inter-individual variability in IL-23-induced signal transduction in circulating human lymphocytes has not been well-defined. In this study, we observed marked, reproducible inter-individual differences in IL-23 responsiveness (measured by STAT3 phosphorylation) in p...

2010
Philip P. Ahern Chris Schiering Sofia Buonocore Mandy J. McGeachy Dan J. Cua Kevin J. Maloy Fiona Powrie

Mutations in the IL23R gene are linked to inflammatory bowel disease susceptibility. Experimental models have shown that interleukin-23 (IL-23) orchestrates innate and T cell-dependent colitis; however, the cell populations it acts on to induce intestinal immune pathology are unknown. Here, using Il23r(-/-) T cells, we demonstrated that T cell reactivity to IL-23 was critical for development of...

Journal: :Journal of immunology 2010
Lorena Riol-Blanco Vanja Lazarevic Amit Awasthi Meike Mitsdoerffer Brian S Wilson Andy Croxford Ari Waisman Vijay K Kuchroo Laurie H Glimcher Mohamed Oukka

IL-23 plays an important role in autoimmune tissue inflammation and induces the generation of not fully characterized effector cells that mediate protection against pathogens. In this paper, we established the essential role of IL-23R in the host response against intracellular pathogens. IL-23 was critical for the expansion or maintenance of gammadelta and double negative (DN) alphabeta T cells...

2009
Philippa Hillyer Maggie J. Larché Edward P. Bowman Terrill K. McClanahan Rene de Waal Malefyt Lauren P. Schewitz Grey Giddins Marc Feldmann Robert A. Kastelein Fionula M. Brennan

OBJECTIVE IL-23 is a pro-inflammatory cytokine proposed to be central to the development of autoimmune disease. We investigated whether IL-23, together with the downstream mediator IL-17A, was present and functional in RA in humans. METHODS RA synovial cells were cultured in the presence or absence of antibodies directed against IL-23p19 or -23R and -17. IL-23, -12, -17, and their receptors, ...

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