Objective(s): In the present study,a new series of 6-methoxy-2-arylquinoline analogues was designed and synthesized as P-glycoprotein (P-gp) inhibitors using quinine and flavones as the lead compounds. Materials and Methods: The cytotoxic activity of the synthesized compounds was evaluated against two human cancer cell lines including EPG85-257RDB, multidrug-resistant gastric carcinoma cells (P...

membrane permeability and p-glycoprotein (p-gp) efflux system are regulating factors in the drug brain penetration. recently, some drug delivery systems have been developed to overcome these limitations. in this study, metoclopramid has been encapsulated in plga nanoparticles using the emulsification/solvent evaporation technique for in vitro evaluation of the effect of plga nanoparticles on bb...

Objective(s):Transporters have an important role in pharmacokinetics of drugs. Inhibition or induction of drug transporters activity can affect drug absorption, safety, and efficacy. P-glycoprotein (P-gp) is the most important membrane transporter that is responsible for active efflux of drugs. It is important to understand which drugs are substrates, inhibitors, or inducers of P-gp to minimize...

several transporters appear to be important in transporting various drugs. many patients, who receive morphine as analgesic medication, also receive other medications with potency of changing morphine transport by affecting p-glycoprotein (p-gp) and oatp2 transport system. this could influence morphine pharmacokinetics and pharmacodynamics. the aim of present study was to elucidate the transpor...