Impairment or interruption of oxygen supply compromises brain function and plays a role in neurological and neurodegenerative conditions. Creatine is a naturally occurring compound involved in the buffering, transport, and regulation of cellular energy, with the potential to replenish cellular adenosine triphosphate without oxygen. Creatine is also neuroprotective in vitro against anoxic/hypoxi...

We studied the effects of graded exposure to hyperbaric (1,875 mm Hg) oxygen therapy in an acute stroke model prepared by unilateral carotid artery interruption in gerbils. Pentobarbital alone, superoxide dismutase alone, two periods of hyperbaric oxygen alone, and each agent combined with hyperbaric oxygen were administered to investigate possible mechanisms of protection from cerebral ischemi...

The aim of this study was to evaluate the effects of severe acute hypoxia on exercise performance and metabolism during 30-s Wingate tests. Five endurance- (E) and five sprint- (S) trained track cyclists from the Spanish National Team performed 30-s Wingate tests in normoxia and hypoxia (inspired O(2) fraction = 0.10). Oxygen deficit was estimated from submaximal cycling economy tests by use of...

abstarct background: base deficit is a non-respiratory indicator of acid base status that evaluates the severity of shock at the cellular level. base deficit results from cellular metabolism of pyruvate under anaerobic conditions. in this situation, base deficit is a sensitive marker of the magnitude of anaerobic metabolism and tissue oxygen deficit [1]. several studies have shown a strong posi...

This paper discusses certain aspects of the metabolic acidosis which accompanies heavy exercise, concentrating on the factors influencing hydrogen ion production and the associated effects on carbon dioxide output and ventilation. Classical concepts of lactic acidosis in exercise were established many years ago (Hill, 1932; Margaria, Edwards & Dill, 1933) and continue to be widely accepted. In ...

INTRODUCTION Hemorrhagic shock induced O2 deficit triggers inflammation and multiple organ failure (MOF). Endogenous H2S has been proposed to be involved in MOF since plasma H2S concentration appears to increase in various types of shocks and to predict mortality. We tested the hypothesis that H2S increases during hemorrhagic shock associated with O2 deficit, and that enhancing H2S oxidation by...

Oxygen actual and relative deficits in Jurumirim Reservoir were computed from the temperature and dissolved oxygen profiles determined in a study from March 1988 to March 1989. The reservoir presented an isothermy from June to September and a thermal stratification from October to March. Thermocline was always located at the 1/3 deeper zone of the-water column. Clinograde oxygen profiles were o...

Incubation of 3-d-old seedlings of Oryza sativa L. cv Arborio under anaerobic conditions, leads to a large increase in the titer of free putrescine while aerobic incubation causes a slight decrease. After 2 days, the putrescine level is about 2.5 times greater without oxygen than in air. The rice coleoptile also accumulates a large amount of bound putrescine and, to a lesser extent, spermidine ...