Background: Primary nocturnal enuresis is a common disorder that often leads to considerable distress in affected children and their family. In many countries pharmacologic therapy is preferred to non-pharmacologic behavioral and conditional alarm therapy. Imipramine, oxybutynin, and desmopressin have been used for enuresis with various efficacies. The aim of the present study was to compare th...

Hypothesis / aims of study Children with spinal cord disorders can present with neurogenic bladder, a condition in which the bladder partly or completely loses its ability to store urine and void at low pressure. A bladder with low compliance may cause urinary incontinence, which negatively impacts quality of life and renal function. Long-term high pressure neurogenic bladder can increase the r...

BACKGROUND Flexible dosing of anticholinergics used for overactive bladder (OAB) treatment is a useful strategy in clinical practice for achieving a maximum effective and maximum tolerated level of therapeutic benefit. In this post hoc analysis we evaluated the efficacy and tolerability of trospium chloride treatment for urinary urge incontinence (UUI) with focus on flexible dosing. METHODS T...

BACKGROUND Nocturnal enuresis is the most common pediatric urologic problem in outpatient clinics. OBJECTIVES To assess the effect of various monotherapies, and comparing the effects of desmopressin, imipramine, and oxybutynin in children with enuresis, as well as the influence of socioeconomic and cultural factors of their families on the response and relapse rates. PATIENTS AND METHODS Th...

Correspondence: Stephen r Kraus University of Texas Health Science Center at San Antonio, Department of Urology, 7703 Floyd Curl Drive, MC, 7845, San Antonio, Texas 78229, USA Tel +1 (210) 567-5676 Fax +1 (210) 567-6868 email [email protected] Abstract: Overactive bladder (OAB) is a common condition which negatively impacts the quality of life of afflicted patients. This can result in alterati...

BACKGROUND Antimuscarinic agents are the most popular treatment for overactive bladder and their efficacy in man is well documented, producing decreased urinary frequency and an increase in bladder capacity. During cystometry in rats, however, the main effect reported after acute treatment with antimuscarinics is a decrease in peak micturition pressure together with little or no effect on bladd...

nence Society (ICS) as symptoms of urgency with or without urge incontinence, usually with increased frequency and nocturia. Since both normal voiding processes and involuntary detrusor contractions during bladder filling are mediated by muscarinic receptors, anticholinergic agents, such as oxybutynin, are currently recommended as first-line therapy for the treatment of overactive bladder. Alth...

An antimuscarinic therapy may increase the risk of voiding dysfunction. However, it is unclear whether the relative risk of voiding dysfunction is different among antimuscarinics. Therefore we determined the potencies both in enhancing the bladder capacity (BC), effectiveness, and in decreasing the maximum urinary flow rate (Qmax), voiding dysfunction, to compare their therapeutic indices.Under...