BACKGROUND Portacaval shunting in rats produces a reduction of hepatic oxidant scavenging ability. Since this imbalance in hepatic oxidant/antioxidant homeostasis could coexist with systemic changes of oxidant stress/antioxidant status, plasma oxidants and antioxidant redox status in plasma of portacaval shunted-rats were determined. RESULTS Male Wistar male: Control (n = 11) and with portaca...

introduction: the molecular mechanisms involved in pathogenesis of esophageal cancer have been the main concern of several studies. in this study, we aimed to investigate the changes of serum prooxidant-antioxidant balance (pab) value as a redox index, as well as serum c-reactive protein (crp) compared to healthy control group. materials and methods: in a cross-sectional study, blood samples we...

The effects of Ocimum basilicum (O. basilicum) and its constituent, rosmarinic acid, on total and differential blood WBC, serum levels of NO2, NO3, MDA, thiol, SOD and CAT in sensitized rats were examined. The study was performed in control animals (group C) and eight groups of sensitized rats to ovalbumin which were given drinking water alone (group S), drinking water containing three concentr...

OBJECTIVES To determine the serum and tissue levels of markers of impaired oxidative metabolism and correlate these levels with the histopathology and Alvarado score of acute appendicitis patients. METHOD Sixty-five acute appendicitis patients (mean age, 31.4±12.06 years; male/female, 30/35) and 30 healthy control subjects were studied. The Alvarado score was recorded. Serum samples were obta...

BACKGROUND/AIMS Helicobacter pylori infection has been suggested to be associated with atherosclerosis. The issue is still controversial. It is well known that abnormal lipid profile and oxidative stress are related to atherosclerosis and the measurement of carotid intima-media thickness. The aim of this study was to investigate carotid intima-media thickness and oxidative stress along with lip...

Objective: Iron is an element, which found in the structure of antioxidant enzymes and has important role inactivation reactive oxygen species. Disruption oxidant-antioxidant balance may be playing a pathogenesis iron deficiency anemia (IDA). Dynamic thiol-disulfide homeostasis (DTDH) serum ischemia-modified albumin (IMA) levels are indicators pro-oxidant/antioxidant status. In this study, we a...

OBJECTIVE To explore the hepatoprotective and anti-oxidant activities of the methanolic leaf extract of Bridelia micrantha (B. micrantha) on paracetamol induced liver damage in Wistar rats. METHODS Parameters were measured including alanine aminotransaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), bilirubin and total protein. The anti-oxidant effects were studied ...

The development of a convenient mathematical application for testing the antioxidant and prooxidant potential of standard and novel therapeutic agents is essential for the research community and food industry in order to perform more precise evaluations of products and processes. In this work, a simple non-linear dose-time tool to test the effectiveness of compounds for competitive assays is pr...

results a significant higher serum pab value was observed in shift working and daytime nurses (152.28 ± 43.64 hk) in comparison to the control group (63.64 ± 34.41 hk index), p value = 0.001. in day time nurses, also serum pab between male (119.09 ± 47.14 hk) and female (162.53 ± 37.02 hk) in nursing workers was significant, p value = 0.005. in the night shift working nurses, there was also a s...

objective: crocin, the carotenoid isolated from saffron, has numerous medicinal properties which include anticancer and antioxidant activities. some antioxidants, such as carotenoids, can act as pro-oxidants at higher dosages and therefore induce tissue damage. in this situation antioxidant defense systems in the liver activate to prevent tissue damage. this study investigates the possible toxi...