نتایج جستجو برای: oxadiazol denvativesl differential pulsevoltammary

تعداد نتایج: 285294  

Journal: :Chemical communications 2016
Jiajia Luo Guohua Xie Shaolong Gong Tianheng Chen Chuluo Yang

We designed and synthesized a single polymer with TADF characteristics by grafting the TADF emitter, 10-(4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl)-10H-phenoxazine, onto the side chain of the polymer backbone of polycarbazole. Employing these copolymers as emitting layers, an efficient bluish-green polymer LED with a maximum external quantum efficiency of 4.3% was achieved, corresponding to a hig...

2011
Mohammad Amir Khalid Saifullah Wasim Akhter

A series of substituted 1,3,4-oxadiazole derivatives 2a-e and 4a-e have been synthesized from diphenyl acetic acid hydrazide under various reaction conditions. These compounds have been tested in-vivo for their anti-inflammatory and analgesic activities. The compound 2-[(5-diphenylmethyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-(3-chloro-4-fluro-phenyl)acetamide 4b has emerged as the most active compou...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2008
Benjamin M Johnson Amrita V Kamath John E Leet Xiaohong Liu Rajeev S Bhide Ravindra W Tejwani Yueping Zhang Ligang Qian Donna D Wei Louis J Lombardo Yue-Zhong Shu

5-Isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737) is a potent and selective vascular endothelial growth factor receptor-2 antagonist. In this study, liquid chromatography/tandem mass spectrometry and NMR were used to investigate the biotransformation of BMS-645737 in vitro and in the cynomolgus monkey, dog, ...

2012
Juan Zheng Wen-juan Li Manman Song Yan Xu

In the crystal structure of the title compound, C(9)H(9)N(3)O, adjacent mol-ecules are linked through N-H⋯N hydrogen bonds into a three-dimensional network.

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2004
Masashi Mise Seiji Yadera Michiaki Matsuda Takanori Hashizume Satoshi Matsumoto Yoshiaki Terauchi Toshihiko Fujii

5-(3-methoxyphenyl)-3-(5-methyl-1,2,4-oxadiazol-3-yl)-2-oxo-1,2-dihydro-1,6-naphthyridine (AC-3933) is a novel cognitive enhancer with central benzodiazepine receptor partial inverse agonistic activity. AC-3933 is predominantly metabolized to hydroxylated metabolite [SX-5745; 3-(5-hydroxymethyl-1,2,4-oxadiazol-3-yl)-5-(3-methoxyphenyl)-2-oxo-1,2-dihydro-1,6-naphthyridine] in dog. Initially, we ...

Journal: :Molecules 2012
Aušra Voskienė Birutė Sapijanskaitė Vytautas Mickevičius Ilona Jonuškienė Maryna Stasevych Olena Komarovska-Porokhnyavets Rostyslav Musyanovych Volodymyr Novikov

New 3-substituted 1-(3-hydroxyphenyl)-5-oxopyrrolidine derivatives containing hydrazone, azole, diazole, oxadiazole fragments, as well as 2-phenoxy- and 2,3-diphenoxy-1,4-naphthoquinone derivatives were synthesized. The structure of all compounds has been confirmed by NMR, IR, mass spectra, and elemental analysis data. Methyl 1-{3-[(3-chloro-1,4-dioxo-1,4-dihydro-2-naphthalenyl)oxy]phenyl}-5-ox...

Journal: :Acta Crystallographica Section C Crystal Structure Communications 2004

2011
Hoong-Kun Fun Madhukar Hemamalini Nithinchandra Balakrishna Kalluraya

In the title syndone (1,2,3-oxadiazol-3-ylium-5-olate) compound, C(21)H(16)ClN(5)O(4)S, the dihedral angle between the benzene and oxadiazole rings is 55.62 (11)° and that between the triazine and the chloro-substituted phenyl rings is 82.45 (9)°. There is an intra-molecular C-H⋯S hydrogen bond, which generates an S(5) ring motif. In the crystal, inversion dimers linked by pairs of C-H⋯O hydrog...

Journal: :Molecules 2017
Ahmet Özdemir Belgin Sever Mehlika Dilek Altıntop Halide Edip Temel Özlem Atlı Merve Baysal Fatih Demirci

Matrix metalloproteinases (MMPs) are important proteases involved in tumor progression including angiogenesis, tissue invasion, and migration. Therefore, MMPs have been reported as potential diagnostic and prognostic biomarkers in many types of cancer. New oxadiazole, thiadiazole, and triazole derivatives were synthesized and evaluated for their anticancer effects on A549 human lung adenocarcin...

Journal: :Archiv der Pharmazie 2001
A Kocabalkanli O Ates G Otük

5-Phenyl/methyl-5-morpholinomethyl/pyrrolidinomethyl-2-(5- aryl-1,3,4-oxadiazol-2-yl)imino]-4-thiazolidinones (5a-m) were synthesized by the reaction of 5-phenyl/methyl-2-[(5-aryl-1,3,4-oxadiazol -2-yl)imino]-4-thiazolidinones (4a-j) with formaldehyde and morpholine or pyrrolidine. The structures of the compounds were determined by analytical and spectral (IR, 1H-NMR, EIMS) methods. The antibac...

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