The mitochondrial pathway of apoptosis involves a complex interplay between dozens of proteins and lipids, and is also dependent on the shape and size of mitochondria. The use of cellular models in past studies has not been ideal for investigating how the complex multi-factor interplay regulates the molecular mechanisms of mitochondrial outer membrane permeabilization (MOMP). Isolated systems h...

One of our major research interests is to define BCL-2 family function in the cellular decision to induce mitochondrial outer membrane permeabilization and apoptosis. Curiosity in BCL-2 family - mitochondrial interactions led to the identification that the sphingolipid pathway plays a crucial role in BCL-2 family function. For approximately 20 years, sphingolipid biology and apoptotic mechanism...

The axially compressed buckling of a double-walled carbon nanotabe surrounded by an elastic medium using the energy and the Rayleigh-Ritz methods is investigated in this paper. In this research, based on the elastic shell models at nano scale, the effects of the van der Waals forces between the inner and the outer tubes, the small scale and the surrounding elastic medium on the critical bucklin...

introduction: the objective of this study was to compare the shaping ability of three rotary filing systems; constant taper k3 instruments, constant taper profile instruments and progressive taper protaper rotary instruments in clear resin blocks with simulated curved root canals. materials and methods: forty five resin blocks were divided into three groups. group a preparation was conducted wi...

bordetella pertussis infects the respiratory tract of the human host and causes whooping cough in children. the nature of immunity against bordetella pertussis infection and disease is poorly understood. the aim of this study was to investigate cell mediated immunity in mice immunized with outer membrane component of cell wall, of b. pertussis. a group of mice were immunized with outer membrane...

This paper is devoted to deformation theory of "anabelian" representations of the absolute Galois group landing in outer automorphism group of the algebraic fundamental group of a hyperbolic smooth curve defined over a number-field. In the first part of this paper, we obtained several universal deformations for Lie-algebra versions of the above representation using the Schlessinger criteria for...

In this work, incremental sheet forming of a complicated shape is investigated experimentally. Two point incremental forming with negative and positive dies are employed for manufacturing of a complicated shape with positive and negative truncated cones. The material is aluminum alloy 3105 with a thickness of 1 mm. The effects of process parameters such as sequence of positive and negative form...

This paper investigates symmetrical buckling of orthotropic circular and annular plates of continuous variable thickness. Uniform compression loading is applied at the plate outer boundary. Thickness varies linearly along radial direction. Inner edge is free, while outer edge has different boundary conditions: clamped, simply and elastically restraint against rotation. The optimized Ritz method...