The variety of factors that contributed to the initial undetected spread of Ebola virus disease in West Africa during 2013-2016 and the difficulty controlling the outbreak once the etiology was identified highlight priorities for disease prevention, detection, and response. These factors include occurrence in a region recovering from civil instability and lacking experience with Ebola response;...

an outbreak of a lethal disease was reported in 4–6-month-old holstein calves in a feedlot around tehran. the signs of central nervous system and gastrointestinal system (gi) involvement were observed in the diseased animals. necropsy samples of gi, liver, kidney, spleen and lung from 3 died animals were prepared for histopathological examination. blood and formalin-fixed ear notch samples of 6...

As the global eradication of poliomyelitis approaches the final stages, prompt detection of new outbreaks is critical to enable a fast and effective outbreak response. Surveillance relies on reporting of acute flaccid paralysis (AFP) cases and laboratory confirmation through isolation of poliovirus from stool. However, delayed sample collection and testing can delay outbreak detection. We inves...

Introduction The New York City (NYC) syndromic surveillance system has monitored syndromes from NYC emergency department (ED) visits since 2001, using the temporal and spatial scan statistic in SaTScan for aberration detection. Since our syndromic system was initiated, alternative methods have been proposed for outbreak identification. Our goal was to evaluate methods for outbreak detection and...

From 2014 to 2015, we investigated a suspected nationwide outbreak of enterohemorrhagic Escherichia coli serogroup O121. However, similar pulsed field gel electrophoresis (PFGE) profiles and the lack of epidemiological links between the isolates made detection of the outbreak difficult. To elucidate a more precise genetic distance among the isolates, whole genome sequence (WGS) analyses were im...

This paper discusses computer-supported outbreak detection using routine surveillance data, as implemented at six institutes for infectious disease control in five European countries. We give an overview of the systems used at the Statens Serum Institut (Denmark), Health Protection Agency (England, Wales and Northern Ireland), Robert Koch Institute (Germany), Governmental Institute of Public He...

Early detection of disease outbreaks is of paramount importance to implementing intervention strategies to mitigate the severity and duration of the outbreak. We build methodology that utilizes the characteristic profile of disease outbreaks to reduce the time to detection and false positive rate. We model daily counts through a Poisson distribution with additive background plus outbreak compon...

Early detection of disease outbreaks, particularly an outbreak due to an act of bioterrorism, is a critically important problem due to the potential to reduce both morbidity and mortality. One of the most lethal bioterrorism scenarios is a large-scale release of inhalational anthrax. The Population-wide Anomaly Detection and Assessment (PANDA) algorithm [1] is specifically designed to monitor h...

An adenovirus outbreak occurred in New Haven, Connecticut in 2006-2007. Molecular typing revealed a twofold increase in adenovirus type 3 infections. Restriction enzyme analysis (REA) indicated that the CT outbreak was largely due to a marked increase in the novel Ad3a51 strain. This outbreak represents the first detection of Ad3a51 in the United States. While most infections were mild, childre...