OBJECTIVE PET imaging is possible with copper (Cu) isotopes, (60)Cu, (61)Cu, (62)Cu and (64)Cu. Although (62)Cu- and (64)Cu-labeled radiotracers are often used for preclinical and clinical PET studies, we do not know which radiotracers have better image quality for tumor imaging. In this study, we compare image quality between (62)Cu and (64)Cu imaging with a different acquisition mode and reco...

objective(s): the aim of this study was to determine the optimal reconstruction parameters for iterative reconstruction in different devices and collimators for dopamine transporter (dat) single-photon emission computed tomography (spect). the results were compared between filtered back projection (fbp) and different attenuation correction (ac) methods.methods: an anthropomorphic striatal phant...

Objective(s): We evaluated edge artifacts in relation to phantom diameter and reconstruction parameters in point spread function (PSF)-based positron emission tomography (PET) image reconstruction.Methods: PET data were acquired from an original cone-shaped phantom filled with 18F solution (21.9 kBq/mL) for 10 min using a Biograph mCT scanner. The images were reconstructed using the baseline or...

UNLABELLED The aim of this study was to investigate the effects of the point-spread function (PSF) and time-of-flight (TOF) on improving (18)F-FDG PET/CT images in relation to reconstruction parameters and noise-equivalent counts (NEC). METHODS This study consisted of a phantom study and a retrospective analysis of 39 consecutive patients who underwent clinical (18)F-FDG PET/CT. The body phan...

Positron emission tomography (PET) is a popular research topic. People are becoming more interested in PET images as they become widely available. However, the partial volume effect (PVE) remains one of most influential factors causing resolution to degrade. It possible reduce this PVE and achieve better image quality by measuring modeling point spread function (PSF) then accounting for it insi...

UNLABELLED Iterative reconstruction has become the standard for routine clinical PET imaging. However, iterative reconstruction is computationally expensive, especially for time-of-flight (TOF) data. Block-iterative algorithms such as ordered-subsets expectation maximization (OSEM) are commonly used to accelerate the reconstruction. There is a tradeoff between the number of subsets and reconstr...

It is expected that both noise and activity distribution can have impact on the detectability of a myocardial defect in a cardiac PET study. In this work, we performed phantom studies to investigate the detectability of a defect in the myocardium for different noise levels and activity distributions. We evaluated the performance of three reconstruction schemes: Filtered Back-Projection (FBP), O...

Introduction: Quantitative evaluation is recommended to improve diagnostic ability and serial assessment of dopamine transporter (DAT) density scans. We decided to compare the ordered subsets expectation-maximization (OSEM) with filtered back-projection (FBP), and to investigate the impact of different iteration and cut-off frequencies on SBR values. Methods</stro...

Site-specific investigations of the role of radiomics in cancer diagnosis and therapy are emerging. We evaluated the reproducibility of radiomic features extracted from 18 Flourine-fluorodeoxyglucose (18 F-FDG) PET images for three parameters: manual versus computer-aided segmentation methods, gray-level discretization, and PET image reconstruction algorithms. Our cohort consisted of pretreatme...