1. Propetamphos is an organophosphorus compound. Technical grade propetamphos consists of 4 isomers, 2 geometric (cis and trans) isomers and 2 optical (Sand R-)isomers. The cis form predominates as the active ingredient, usually exceeding 90% w/w of the technical material. From analogy with the chiral separation of propetamphos-oxon, cis-propetamphos is a racemate of equal proportions of the Sa...

A series of phenoxyoxazaphospholidine, phenoxyoxazaphosphinane and benzodioxaphosphininamine sulfides and related cyclic organophosphorus compounds based on the lead anti-tubulin herbicides amiprophos methyl and butamifos were synthesised and evaluated for anti-malarial activity. Of these compounds, while none of the phenoxyoxazaphospholidines, phenoxyoxazaphosphinanes or benzodioxaphosphininam...

was discussed. This compound is a member of a group of organophosphorus insecticides which are powerful inhibitors of cholinesterases. They will also inhibit chymotrypsin, and it has been shown that this inhibition is due to combination of the compounds with a single active centre in the enzyme (Jansen, Nutting & Balls, 1949; Hartley & Kilby, 1952).We investigated the reaction ofchymotrypsin wi...

Organophosphorus pesticides have been used extensively especially in tropical countries to control of agricultural pests. However, much of the food we eat contain pesticide residues. Analyses of organophosphorus compounds (OP) residues are carried out worldwide because of their potential health hazardous effect on humans. In this study, hard cheese was monitored for (OP) using ion trap GCMS/MS....

This paper reports the case of a family in which three children were presented at Emergency Room (ER) with poisoning after the use of a pesticide at home. Initially, the cases were managed as routine cases of organophosphorus poisoning; however, the death of two children made the health team members realise that the poison's effects were delayed and devastating. Later, the compound was identifi...

INTRODUCTION Acetylcholinesterase inhibition by organophosphorus pesticides or organophosphate nerve agents can cause acute parasympathetic system dysfunction, muscle weakness, seizures, coma, and respiratory failure. Prognosis depends on the dose and relative toxicity of the specific compound, as well as pharmacokinetic factors. METHODS AND OUTCOMES We conducted a systematic review and aimed...

Certain organic phosphorus esters produce sensorimotor axonopathy in man and other species. There is an excellent correlation between the capacity of an organophosphorus compound to produce axonopathy and its ability to inhibit brain neurotoxic esterase (NTE) in hens. Because NTE is present in peripheral lymphocytes of both hen and man, it has been suggested that the lymphocyte enzyme might be ...