The field of organocatalysis, more specifically asymmetric is continuously expanding having grown significantly over the recent years. However, despite this exponential expansion, ability to determine with any degree certainty reaction mechanisms these types reactions fails keep within pace. Due increasing calculation capacity and methods accuracy, computational methodologies have been establis...

Abstract The application of biocatalysis in conquering challenging synthesis requires the constant input new enzymes. Developing novel biocatalysts by absorbing catalysis modes from synthetic chemistry has yielded fruitful new‐to‐nature Organocatalysis was originally bio‐inspired and become third pillar asymmetric catalysis. Transferring organocatalytic reactions back to enzyme platforms is a p...

Direct C-H functionalization and arylation of benzyl ethers has been accomplished via photoredox organocatalysis. The productive merger of a thiol catalyst and a commercially available iridium photoredox catalyst in the presence of household light directly affords benzylic arylation products in good to excellent yield. The utility of this methodology is further demonstrated in direct arylation ...

Enantioselective desymmetrization of meso-aziridines and meso-epoxides with various nucleophiles by organocatalysis has emerged as a cutting-edge approach in recent years. This review summarizes the origin and recent developments of enantioselective desymmetrization of meso-aziridines and meso-epoxides in the presence of organocatalysts.

An efficient amino acid-/self-/base-/ruthenium-/thermal-catalyzed two-step process for the synthesis of functionalized drug-like carbocycles was achieved through combinations of cascade TCRA/C-allylation/enyne-RCM/Diels-Alder reactions as key steps starting from simple acyclic substrates. In this communication, we report the two-step synthesis of drug-like carbocycles through a combination of o...

Abstract Organic synthesis has traditionally been performed in batch. Continuous-flow chemistry was recently rediscovered as an enabling technology to be applied the of organic molecules. Organocatalysis is a well-established methodology, especially for preparation enantioenriched compounds. In this chapter we discuss use chiral organocatalysts continuous flow. After classification different ty...