A Phase I dose escalation and pharmacokinetic study of the alkylating cytotoxic agent treosulfan was conducted to evaluate the maximum tolerated dose and the dose-limiting toxicities in patients with advanced malignancies rescued by autologous peripheral blood stem cell transplantation. Twenty-two patients (15 ovarian and 7 other carcinomas/lymphomas) with a median age of 48 years were treated ...

background: most preclinical studies are carried out on mice. for internal dose  assessment of a mouse, specific absorbed fraction (saf) values play an important role.  in most studies, saf values are estimated using older standard human organ compositions  and values for limited source target pairs. objective: saf values for monoenergetic photons of energies 15, 50, 100, 500,  1000 and 4000 ke...

Calcitonin gene-related peptide, a 37-amino-acid neuropeptide, has been shown to be widely distributed in periadventitial nerves throughout the cardiovascular system, particularly in association with coronary arteries. In vivo and in vitro studies have demonstrated that calcitonin gene-related peptide possesses potent vasodilator properties. Circulating calcitonin gene-related peptide is derive...

chlorotoxin is a 36 amino acids peptide, which is able to block chloride channels isolated from mouse brain. a derivative of chlorotoxin is synthesized and it is labeled by iodine 131; then animal experiments carry out on rats. multiple organ doses may be calculated with biological distribution results in rats with labeled compounds using simulated mcnp4c code. human dose can be calculated usin...

Introduction: The study aimed to assess absorbed and effective doses in organs through computed tomography (CT) examinations using automatic exposure control (AEC) and fixed tube current (FTC) techniques. Material and Methods: Scanning parameters were obtained for routine adult CT examinations and used to estimate the organ absorbed and effec...

Introduction: Quality assurance in Computed tomography (CT) centers in developing countries are largely hindered by the unavailability of CT phantoms. The development of a local CT phantom for the measurement of organ radiation absorbed dose is therefore requisite. Material and Methods: Local CT phantoms were designed to meet the standard criteria of 32 cm diameter for body, 16 cm diameter for...

BACKGROUND The decrease in peripheral blood lymphocytes induced by radiation lessens the antitumour effect of the immune response, which might cause immunosuppression. We aimed to investigate the correlation between the decrease in peripheral blood lymphocytes during radiotherapy (RT) and the spleen irradiation dose in patients with hepatocellular carcinoma (HCC). METHODS The subjects were 59...