Organic Rankine cycle (ORC) system is considered as a promising technology for energy recovery from the waste heat rejected by internal combustion (IC) engines. However, such waste heat is normally contained in both coolant and exhaust gases at quite different temperatures. A single ORC system is usually unable to efficiently recover energy from both of these waste heat sources. A dual loop ORC...

ORC (origin recognition complex) serves as the initiator for the assembly of the pre-RC (pre-replication complex) and the subsequent DNA replication. Together with many of its non-replication functions, ORC is a pivotal regulator of various cellular processes. Notably, a number of reports connect ORC to numerous human diseases, including MGS (Meier-Gorlin syndrome), EBV (Epstein-Barr virus)-inf...

Orc is a kernel language for structured concurrent programming. Orc provides three powerful combinators that define the structure of a concurrent computation. These combinators support sequential and concurrent execution, and concurrent execution with blocking and termination. Orc is particularly well-suited for task orchestration, a form of concurrent programming with applications in workflow,...

Organic Rankine Cycle (ORC) systems are capable of utilising low-enthalpy geothermal sources. The aim of the Above Ground Geothermal and Allied Technologies (AGGAT) research programme is the development of ORC systems within New Zealand. An experimental scale ORC system, known as ORC-B, was built at the University of Canterbury to assist with the research and development of the system design an...

Genome-wide experimental studies in Saccharomyces cerevisiae reveal that autonomous replicating sequence (ARS) requires an essential consensus sequence (ACS) for replication activity. Computational studies identified thousands of ACS like patterns in the genome. However, only a few hundreds of these sites act as replicating sites and the rest are considered as dormant or evolving sites. In a bi...

This report describes a distributed implementation of an interpreter for the computation orchestration language ORC. While ORC includes primitives for distributed computation in the form of “sites”, these have limitations and it is difficult to convert a non-distributed ORC program into a distributed one. I therefore introduce a new syntax for annotating distributable expressions in an existing...

BACKGROUND The limitation of carbonyl reduction represents one possible way to increase the effectiveness of anthracycline doxorubicin (DOX) in cancer cells and decrease its toxicity in normal cells. In vitro, isoquinoline derivative oracin (ORC) inhibited DOX reduction and increased the antiproliferative effect of DOX in MCF-7 breast cancer cells. Moreover, ORC significantly decreases DOX toxi...

The origin recognition complex (ORC), a heteromeric six-subunit protein, is a central component for eukaryotic DNA replication. The ORC binds to DNA at replication origin sites in an ATP-dependent manner and serves as a scaffold for the assembly of other key initiation factors. Sequence rules for ORC-DNA binding appear to vary widely. In budding yeast the ORC recognizes specific ori elements, h...

A bacterial strain designated Orc-4(T) was isolated from a freshwater spring in Taiwan and characterized using the polyphasic taxonomic approach. Cells of strain Orc-4(T) were facultatively anaerobic, Gram-reaction-negative, poly-β-hydroxybutyrate-accumulating, non-motile rods surrounded by a thick capsule and forming cream-white colonies. Growth occurred at 15-40 °C (optimum, 25-30 °C), at pH ...

The role of the natural HMR-E silencer in modulating replication initiation and silencing by the origin recognition complex (ORC) was examined. When natural HMR-E was the only silencer controlling HMR, the silencer's ORC-binding site (ACS) was dispensable for replication initiation but essential for silencing, indicating that a non-silencer chromosomal replicator(s) existed in close proximity t...