BACKGROUND It is generally accepted that the development of cancer in the oral mucosa is preceded by an identifiable non-invasive precursor lesion. The aim of this follow-up study was to estimate the rate and the time to transformation in a group of patients from southern Taiwan with potentially malignant oral epithelial lesions. METHODS The follow-up time is defined as the duration between t...

This cross-sectional study was conducted to evaluate the prevalence of oral sub-mucous fibrosis among male school going children in a low socio-economic class and to analyze the relationship between oral submucous fibrosis and the use of various form of tobacco and areca nut. It was conducted on 54 male school going children aged between 10-19 years studying in classes VI to X of a public schoo...

Oral submucous fibrosis (OSF) is caused by aberrant collagen deposition in the oral mucosa. A chronic, creeping, scarring disease of cavity often involving pharynx and upper oesophagus how it's been described for centuries. It most dangerous premalignant condition evolve into malignant tumours 1.5% to 15% cases. found primarily India, Pakistan, Sri Lanka, Bangladesh. Submucous fibrosis, ulcerat...

Oral submucous fibrosis (OSF) is a chronic, insidious disease. The presence of autoantibodies in sera of OSF patients is the most characteristic and direct evidence of OSF being an autoimmune disease. To identify the specific autoantigens which could contribute to antibody production, the Human Proteome Microarrays composed of 19000 full-length unique proteins were employed. 45 proteins correla...

24 Review Article ORAL SUBMUCOUS FIBROSIS: AN UPDATE ON ETIOLOGY AND PATHOGENESIS-A REVIEW Shukla A, Singh A, Srivastava R Abstract: Oral submucous fibrosis (OSMF) is a chronic disease of oral mucosa characterized by inflammation and progressive fibrosis followed by stiffening of an otherwise yielding mucosa resulting in difficulty in opening the mouth. It is generally accepted today that areca...

This article describes a male patient who presented with trismus due to submucous fibrosis and how in course of time it turned malignant into oral squammous cell carcinoma. Oral submucous fibrosis (OSF) is a chronic, complex, irreversible, highly potent pre-cancerous condition characterized by juxta-epithelial inflammatory reaction and progressive fibrosis of the submucosal tissues (lamina prop...

Oral submucous fibrosis is a chronic, insidious disease affecting the oral cavity and sometimes pharynx. Although occasionally preceded and/or associated with vesicle formation, is always associated with juxtaepithelial inflammatory reaction followed by fibro elastic changes in lamina propria with epithelial atrophy leading to stiffness of oral cavity leading to trismus and inability to eat. Al...

BACKGROUND Oral submucous fibrosis is a chronic, insidious oral mucosal condition affecting the most parts of the oral cavity with high malignant transformation rate triggered by areca nut chewing, nutritional deficiencies, immunologic processes, and genetic predisposition. OSF causes significant hematological abnormalities resulting in anemia and a decrease in serum iron levels. AIM The aim ...

Oral submucous fibrosis (OSMF) is a crippling disorder which is confined almost exclusively to the Indian subcontinent. Despite its association with a significantly increased risk of cancer, the etiology is still not clear. An epidemiological assessment showed 0.4% prevalence for OSMF in Kerala, South India, which is among the highest recorded. Recently the National Tumour Registry in Trivandru...