BACKGROUND AND AIM: Oral lichen planus (OLP) is a chronic, autoimmune, inflammatory disease. The progression of OLP to oral squamous cell carcinoma (OSCC) has generated a longstanding controversy about the details of this malignant transformation potential. This study aimed to do a systematic review on the molecular markers related to the malignant transformation of OLP.METHODS: We searched the...

Introduction: Oral squamous cell carcinoma (OSCC) is one of the 10 most common malignant tumors and SCC accounts 94% of all oral malignancies. Mast cells are regarded as complex and multifunctional cells, playing a significant role in immunopathology . The aim of this study is to evaluate the number of mast cells in tissue sections of oral squamous cell carcinoma (OSCC) in comparison with norma...

Changes in Salivary Antioxidants Patients with Oral Squamous Cell Carcinoma: Systematic Review Study and Meta-Analysis

metastases of internal tumors to the oral cavity are unusual and in most cases involve maxilla and mandible. metastases to the gingival soft tissue are extremely rare. reporting a new clinical case of renal cell carcinoma (rcc) metastasis with an unusual site. metastatic involvement of gingival tissue with renal cell carcinoma is an extremely rare clinical event. it is usually associated with i...

statement of the problem: lichen planus is a mucocutaneous disease that is relatively common in middle aged individuals. some studies have shown that oral lichen planus has a potential to progress to squamous cell carcinoma.p21 is a cyclin-dependent kinase inhibitor that regulates the cell cycle, thus it acts as an inhibitor in cell proliferation. purpose: this study was aimed to evaluate and c...

background : angiogenesis is essential for the growth, invasion and metastasis of solid tumors. research on related factors such as microvessel density can be helpful in predicting a tumor's behavior. cd105 has been introduced as a marker of angiogenesis which stains vessels that are in the proliferating stage. there are some controversies about the relation of microvessel density and clinicopa...

background: squamous cell carcinoma (scc) is the most common malignancy in oral cavity. angiogenesis is essential for the development and progression of scc. recently, some studies have reported that mast cells may play a role in tumor progression via promoting angiognesis. since the results of various studies on the role of mast cells in tumor progression is not uniform, the aim of this study ...

Introduction: Eosinophils produce proteases that stimulate invasion in cancers. Due to the more malignant potential of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous cell carcinoma (CSCC), the aim of the present study was to compare tissue eosinophilia between OSCC and CSCC samples to understand whether tissue eosinophilia play a role in different biological...

        Abstract   Squamous cell carcinoma (SCC) is the most common malignant tumors of oral cavity. The ratio of men to women is about 2: 1. Generally, it   is admitted that 60% of carcinoma of the mandibular gingival are located in the posterior of premolars. Gingiva is one of the less common sites of oral squamous cell carcinoma (OSCC). Due to the variable clinical and behavioral presentatio...