PURPOSE Additional targeted therapeutics are needed for the treatment of lymphoma. Abexinostat is an oral pan-histone deacetylase inhibitor (HDACi) displaying potent activity in preclinical models. We conducted a multicenter phase I/II study (N = 55) with single-agent abexinostat in relapsed/refractory lymphoma. EXPERIMENTAL DESIGN In phase I, 25 heavily pretreated patients with any lymphoma ...

Chemotherapy-induced peripheral neuropathy (CIPN) is a well-documented toxicity leading to dose limitation. Ibrutinib an oral Bruton’s Tyrosine Kinase (BTK) inhibitor approved for treating chronic lymphocytic lymphoma. The most common neurological side effects of include headache and dizziness. Herein, we report as dose-limiting manifestation treatment.

Background: The incidence of oral cancers is different worldwide. Objective: To evaluate the rate of oral cancers in Khouzestan Province. Patients and Methods: The data were collected from the pathologic reports of pathology laboratories all around the province, during the time period of 1992-2002. Results: Among the total received specimens, 305 cases of oral cancers were detected. One hundred...

UNLABELLED Lymphoma of the tongue is very rare and accounts for 1% of all malignant tumors of the oral cavity. We present a patient who presented with weakness and difficulties with ambulation who was a known cervical spine spondylosis and stenosis patient. During the preoperative workup for cervical spine surgery a tumor at the base of the tongue was discovered which was confirmed by pathology...

Primary Sjögren's syndrome (pSS) is an autoimmune disorder of the exocrine glands presenting with progressive ocular and oral dryness, parotid gland enlargement, and often with extraglandular manifestations. In this group of patients the risk of development of non-Hodgkin's lymphoma is 16-fold compared to healthy population, mainly of the MALT lymphoma type. This case reports a 52-year-old woma...

Plasmablastic lymphoma (PBL) is an unusual subtype of non-Hodgkin lymphoma recently classified as a diffuse immunoblastic lymphoma with a plasma-cell immunophenotype. Originally described in the oral cavity of HIV-positive patients, it has also been recognized to occur rarely at other sites. We describe a previously unreported fistulizing presentation of Epstein-Barr virus (EBV)-positive PBL, r...

Non-Hodgkin lymphoma (NHL) is the sixth leading cause of cancer death in the United States and accounts for 2–3% of primary neoplasms.1 Plasmablastic lymphoma (PBL) is a rare AIDS-associated NHL of diffuse large B-cell lymphoma (DLBCL) type. It typically presents in HIV infection in the oral cavity.2 Here we discuss a case of a young woman who presented with PBL in the rectum as the initial man...

Case series Oral manifestations of HIV disease are broadly classified as “strongly associated with HIV”, “less commonly associated with HIV” and “can be seen in HIV infection”. Malignancies reported in HIV infection include Kaposi’s sarcoma, Non-Hodgkin’s lymphoma and squamous cell carcinoma of the oral cavity. At our RagasYRG CARE center, in a cohort of 5760 cases which were screened, 6 patien...