introduction: we have recently reported the presence of two potassium currents with 598 and 368 ps conductance in the rough endoplasmic reticulum (rer) membrane. the 598 ps channel was voltage dependent and atp sensitive. however, the 368 ps channel was rarely observed and its identity remained obscure. since cationic channels in intracellular organelles such as mitochondria and rer play import...

One phenomenon that has often puzzled computer science and information systems researchers over the years, particularly researchers interested in e-collaboration issues, is the high importance of having an audio channel for communication in the context of e-collaborative tasks (Graetz et al., 1998; Kock, 2004; Kock & DeLuca, 2007; Wainfan & Davis, 2004). Whenever audio is available (e.g., telec...

background and aims: diabetic nephropathy (dn) is the most common cause of end-stage renal failure which could increase the risk of cardiovascular disease and morbidity and mortality in patients. the aim of this study was to investigate new modalities for treatment of diabetic nephropathy. methods:this study was a mini-review research to investigate drugs that are used for dn treatment. results...

One phenomenon that has often puzzled computer science and information systems researchers over the years, particularly researchers interested in e-collaboration issues, is the high importance of having an audio channel for communication in the context of e-collaborative tasks (Graetz et al., 1998; Kock, 2004; Kock & DeLuca, 2007; Wainfan & Davis, 2004). Whenever audio is available (e.g., telec...

Background and aims: Diabetic nephropathy (DN) is the most common cause of end-stage renal failure which could increase the risk of cardiovascular disease and morbidity and mortality in patients. The aim of this study was to investigate new modalities for treatment of diabetic nephropathy. Methods:This study was a mini-review research to investigate drugs that are used for DN treatment. Resul...

Molecular dynamics simulations of a bacterial potassium channel (KcsA) embedded in a phospholipid bilayer reveal significant differences in interactions of the selectivity filter with K(+) compared with Na(+) ions. K(+) ions and water molecules within the filter undergo concerted single-file motion in which they translocate between adjacent sites within the filter on a nanosecond timescale. In ...

Rapid inactivation of Ca2+ release-activated Ca2+ (CRAC) channels was studied in Jurkat leukemic T lymphocytes using whole-cell patch clamp recording and [Ca2+]i measurement techniques. In the presence of 22 mM extracellular Ca2+, the Ca2+ current declined with a biexponential time course (time constants of 8-30 ms and 50-150 ms) during hyperpolarizing pulses to potentials more negative than -4...

A self-consistent analytic approach is introduced for the estimation of the access resistance and the current through an open ion channel for an arbitrary number of species. For an ion current flowing radially inward from infinity to the channel mouth, the Poisson-Boltzmann-Nernst-Planck equations are solved analytically in the bulk with spherical symmetry in three dimensions, by linearization....

Based on QSAR studies two new DHP calcium-channel blockers, mebudipine and dibudipine, were synthesis and evaluated for their pharmacological activity in various tissues. These studies showed that, these compounds, with potency comparable or greater than that of nifedipine could relax the smooth muscles of various vascular tissues. Electrophysiological study showed that they antagonized calcium...

background: the purpose of this study was to describe the knowledge and attitude of pregnant women in qazvin province, central iran, relating to oral hygiene. methods: the study group comprised of 760 pregnant women living in qazvin, center of iran in 2004. the questions were formulated to evaluate information without the need for dental examination. the age groups between 17-41 years old were ...