Solid cancers develop within a supportive microenvironment that promotes tumor formation and growth through the elaboration of mitogens and chemokines. Within these tumors, monocytes (macrophages and microglia) represent rich sources of these stromal factors. Leveraging a genetically engineered mouse model of neurofibromatosis type 1 (NF1) low-grade brain tumor (optic glioma), we have previousl...

Background and Aim: Optic pathway glioma (OPG) is a chronic condition that needs multidisciplinary management strategy. Most of these tumors are observed in the pediatric population tumor tends to stabilize after child’s growth. This benign course can be mostly neurofibromatosis 1 (NF1) patients, which about half patients. Methods Materials/Patients: The current literature PubMed Scopus databas...

Neurofibromatosis-1 (NF1) is a common tumor predisposition syndrome in which affected individuals develop benign and malignant tumors. Previous studies from our laboratory and others have shown that benign tumor formation in Nf1 genetically engineered mice (GEM) requires a permissive tumor microenvironment. In the central nervous system, Nf1 loss in glia is insufficient for glioma formation unl...

CLINICAL CASE The case of a three-year-old patient with neurofibromatosis type I is presented. Ophthalmologic evaluation revealed, by means of magnetic resonance imaging, the presence of a silent glioma in the optic nerve of the left eye. DISCUSSION Neurofibromatosis-1 can present in multiple ways to the ophthalmologist, with a glioma of the optic nerve being one of the most frequent central ...

Introduction: Malignant astrocytic gliomas are the most common and lethal brain malignancies due to their refractory to the current therapies. Nowadays, molecular targeted therapy has attracted great attention in treatment of glioma. Connexin 43 (Cx43) and micro ribonucleic acid- 21(miR-21) are among molecules that are involved in glioma development and progression. These molecules showed...

AIMS To compare the natural history of sporadic optic glioma with those associated with neurofibromatosis type 1 (NF1). METHODS Optic glioma cases were identified using both the Manchester Children's Tumour Registry (CTR) and the North West Regional NF1 Database (NF1DB), with detailed information on natural history available from the former (in 34 of 36 cases identified). RESULTS A total of...

introduction: malignant astrocytic gliomas are the most common and lethal brain malignancies due to their refractory to the current therapies. nowadays, molecular targeted therapy has attracted great attention in treatment of glioma. connexin 43 (cx43) and micro ribonucleic acid- 21(mir-21) are among molecules that are involved in glioma development and progression. these molecules showed poten...

Solid cancers develop within a supportive microenvironment that promotes tumor formation and growth through the elaboration ofmitogens and chemokines.Within these tumors,monocytes (macrophages andmicroglia) represent rich sources of these stromal factors. Leveraging a genetically engineered mousemodel of neurofibromatosis type 1 (NF1) low-gradebrain tumor (optic glioma), we have previously demo...

Whereas carcinogenesis requires the acquisition of driver mutations in progenitor cells, tumor growth and progression are heavily influenced by the local microenvironment. Previous studies from our laboratory have used Neurofibromatosis-1 (NF1) genetically engineered mice to characterize the role of stromal cells and signals to optic glioma formation and growth. Previously, we have shown that N...