PURPOSE To investigate the effect of optic disc center displacement on retinal nerve fiber layer (RNFL) measurement determined by spectral domain optical coherence tomography (SD-OCT). METHODS The optic disc center was manipulated at 1-pixel intervals in horizontal, vertical, and diagonal directions. According to the manipulated optic disc center location, the RNFL thickness data were resampl...

PURPOSE To investigate the effect of systemic nitric oxide synthase (NOS) inhibition on optic disc oxygen partial pressure (PO(2)) in normoxia and hypercapnia. METHODS Intervascular optic disc PO(2) was measured in 12 anesthetized minipigs by using oxygen-sensitive microelectrodes placed <50 microm from the optic disc. PO(2) was measured continuously during 10 minutes under normoxia, hyperoxi...

PURPOSE To investigate in vitro how the posterior convexity of an intraocular lens (IOL) affected the migration of lens epithelial cells (LECs) under its optic. METHODS Porcine LECs were cultured for 9 days with polymethylmethacrylate (PMMA) IOLs in a cell culture chamber insert containing a collagen membrane on which the IOLs were implanted. The central sagittal optic depths of the implanted...

PURPOSE To design and develop an accommodating intraocular lens (IOL) for endocapsular fixation with extended accommodative range that can be adapted to current standard extracapsular phacoemulsification technique. METHODS Ray tracing analysis and lens design; finite element modeling of biomechanical properties; cadaver eye implantation; initial clinical evaluation. RESULTS Ray tracing anal...

abstract background and aim: consider ing based on the presence or absence of swelling of the optic disc, optic neuritis classified nto two types of anterior and retrobulbar optic neuritis. the aim of this study was to compare the visual functions of patients with anterior optic neuritis and retrobulbar optic neuritis. materials and methods:this cross-sectional study was conducted in 48 patient...

We report on ABB’s fiber-optic current and voltage transducers and their applications in high-voltage substations. We consider bulk-optics and all-fiber current sensors and voltage sensors that exploit the electro-optic effect in BGO and the piezo-electric effect in quartz.

Previous reports showed that short-term hyperglycemia protects optic nerve axons in a rat experimental hypertensive glaucoma model. In this study, we investigated whether short-term hyperglycemia prevents tumor necrosis factor (TNF)-induced optic nerve degeneration in rats and examined the role of autophagy in this axon change process. In phosphate-buffered saline (PBS)-treated rat eyes, no sig...

Corticosteroids shorten the period of functional impairment following relapses in optic neuritis and multiple sclerosis (MS); however they have not, thus far, been shown to affect the final level of function compared with placebo. There has been recent interest in the use of corticosteroids as neuroprotective agents by their effect of decreasing nitric oxide (NO) production by mononuclear cells...