نتایج جستجو برای: optic disc cupping

تعداد نتایج: 87428  

Journal: :Japanese journal of ophthalmology 2001
T Fukuchi J Ueda T Hanyu H Abe S Sawaguchi

PURPOSE Remodeling of the extracellular matrix occurs in the lamina cribrosa in progressed glaucomatous optic nerve damage including disc cupping. We examined immunohistochemical changes in the transforming growth factor (TGF)-beta and platelet-derived growth factor (PDGF) in the optic nerve head in an experimentally induced glaucoma model. METHODS We used 3 cynomolgus and 2 Japanese monkey e...

Journal: :The British journal of ophthalmology 1972
S S Hayreh

Sir William Mackenzie (I835) was the first to describe raised intraocular pressure (IOP) in glaucoma. Following the introduction of the ophthalmoscope, the presence of glaucomatous cupping was soon recognized (Jacobson, I853; Jaeger, I854; von Graefe, 1854; Weber, i 855; and others) and was confirmed histopathologically by Miuller (1856). Mackenzie (i854) described flattened and atrophic nerves...

2014
Henriët. Springelkamp René Höhn Aniket Mishra Pirro G. Hysi Chiea-Chuen Khor Stephanie J. Loomis Jessica N. Cooke Bailey Jane Gibson Gudmar Thorleifsson Sarah F. Janssen Xiaoyan Luo Wishal D. Ramdas Eranga Vithana Monisha E. Nongpiur Grant W. Montgomery Liang Xu Jenny E. Mountain Puya Gharahkhani Yi Lu Najaf Amin Lennart C. Karssen Kar-Seng Sim Elisabeth M. van Leeuwen Adriana I. Iglesias Virginie J. M. Verhoeven Michael A. Hauser Seng-Chee Loon Dominiek D. G. Despriet Abhishek Nag Cristina Venturini Paul G. Sanfilippo Arne Schillert Jae H. Kang John Landers Fridbert Jonasson Angela J. Cree Leonieke M. E. van Koolwijk Fernando Rivadeneira Emmanuelle Souzeau Vesteinn Jonsson Geeta Menon Paul Mitchell Jie Jin Wang Elena Rochtchina John Attia Rodney Scott Elizabeth G. Holliday Tien-Yin Wong Paul N. Baird Jing Xie Michael Inouye Ananth Viswanathan Xueling Sim Robert N. Weinreb Paulus T. V. M. de Jong Ben A. Oostra André G. Uitterlinden Albert Hofman Sarah Ennis Unnur Thorsteinsdottir Kathryn P. Burdon R. Rand Allingham Murray H. Brilliant Donald L. Budenz Jessica N. Cooke Bailey William G. Christen John Fingert David S. Friedman Douglas Gaasterland Terry Gaasterland Jonathan L. Haines Michael A. Hauser Jae Hee Kang Peter Kraft Richard K. Lee Paul R. Lichter Yutao Liu Stephanie J. Loomis Sayoko E. Moroi Louis R. Pasquale Margaret A. Pericak-Vance Anthony Realini Julia E. Richards Joel S. Schuman William K. Scott Kuldev Singh Arthur J. Sit Douglas Vollrath Robert N. Weinreb Janey L. Wiggs Gadi Wollstein Donald J. Zack Kang Zhang Peter Donnelly (Chair) Ines Barroso (Deputy Chair) Jenefer M. Blackwell Elvira Bramon Matthew A. Brown Juan P. Casas Aiden Corvin Panos Deloukas Audrey Duncanson Janusz Jankowski Hugh S. Markus Christopher G. Mathew Colin N. A. Palmer Robert Plomin Anna Rautanen Stephen J. Sawcer Richard C. Trembath Ananth C. Viswanathan Nicholas W. Wood Chris C. A. Spencer Gavin Band Céline Bellenguez Colin Freeman Garrett Hellenthal Eleni Giannoulatou Matti Pirinen Richard Pearson Amy Strange Zhan Su Damjan Vukcevic Peter Donnelly Cordelia Langford Sarah E. Hunt Sarah Edkins Rhian Gwilliam Hannah Blackburn Suzannah J. Bumpstead Serge Dronov Matthew Gillman Emma Gray Naomi Hammond Alagurevathi Jayakumar Owen T. McCann Jennifer Liddle Simon C. Potter Radhi Ravindrarajah Michelle Ricketts Matthew Waller Paul Weston Sara Widaa Pamela Whittaker Ines Barroso Christopher G. Mathew (Chair) Timothy D. Spector Alireza Mirshahi Seang-Mei Saw Johannes R. Vingerling Yik-Ying Teo Jonathan L. Haines Roger C. W. Wolfs Hans G. Lemij E-Shyong Tai Nomdo M. Jansonius Jost B. Jonas Ching-Yu Cheng Tin Aung Ananth C. Viswanathan Caroline C. W. Klaver Jamie E. Craig Stuart Macgregor David A. Mackey Andrew J. Lotery Kari Stefansson Arthur A. B. Bergen Terri L. Young Janey L. Wiggs Norbert Pfeiffer Tien-Yin Wong Louis R. Pasquale Alex W. Hewitt Cornelia M. van Duijn Christopher J. Hammond

Glaucoma is characterized by irreversible optic nerve degeneration and is the most frequent cause of irreversible blindness worldwide. Here, the International Glaucoma Genetics Consortium conducts a meta-analysis of genome-wide association studies of vertical cup-disc ratio (VCDR), an important disease-related optic nerve parameter. In 21,094 individuals of European ancestry and 6,784 individua...

Journal: :The British journal of ophthalmology 1975
J T Schwartz F H Reuling R J Garrison

Clinical measurements of a horizontal cup/disc ratio were obtained among a sample of 160 normal twin subjects by stereoscopic biomicroscopy. Measurements of horizontal cup/disc ratio were normally distributed and theere was no significant association with sex, laterally, race, or refractive error in the mid-range. However, there was a significant association between size of the cup/disc ratio a...

Journal: :Archives of ophthalmology 1985
J R Samples M van Buskirk W T Shults H J Van Dyk

The simultaneous occurrence of both optic nerve head drusen and glaucoma may make it difficult to evaluate visual field defects and the appearance of the optic nerve head. We saw five patients with both conditions, of whom four had pigmentary glaucoma or pigmentary dispersion syndrome. Drusen do not preclude the development of cupping, and they make it difficult to interpret its significance. M...

2018
M. Teut A. Ullmann M. Ortiz G. Rotter S. Binting M. Cree F. Lotz S. Roll B. Brinkhaus

BACKGROUND We aimed to investigate the effectiveness of two different forms of dry pulsatile cupping in patients with chronic low back pain (cLBP) compared to medication on demand only in a three-armed randomized trial. METHODS 110 cLBP patients were randomized to regular pulsatile cupping with 8 treatments plus paracetamol on demand (n = 37), minimal cupping with 8 treatments plus paracetamo...

2009
Marcelo T. Nicolela

Optic nerve-head examination is probably the most important step in the diagnosis of glaucoma and is also extremely important in monitoring patients with established glaucoma. There are several ways to clinically examine the optic nerve head, including direct ophthalmoscopy, indirect ophthalmoscopy, and slit lamp biomicroscopy with contact lenses (such as a Goldman lens), handheld lenses (such ...

Journal: :BMJ case reports 2017
Jayanand Urkude Rashmi Singh Amar Pujari Manthan Hasmukhbhai Chaniyara

Urkude J, et al. BMJ Case Rep 2017. doi:10.1136/bcr-2017-221549 Description Case 1: A posterior segment B-scan ultrasonography in a patient with typical iris coloboma and total cataract, showed well-defined excavated area in the inferior part just below the optic disc (red arrow) with the absence of retinochoroidal layer, suggestive of fundal coloboma (yellow arrow) (figure 1A). Involvement of ...

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