BAG6 participates in protein quality control and, here, we address its role in endoplasmic-reticulum-associated degradation (ERAD) by using the polytopic membrane protein OpD, an opsin degron mutant. Both BAG6 knockdown and BAG6 overexpression delay OpD degradation; however, our data suggest that these two perturbations are mechanistically distinct. Hence, BAG6 knockdown correlates with reduced...

Introduction: Recently combination of diagnostic endoscopy and systematic understanding of the lateral nasal wall with CT in the coronal plane has become the corner stone in the evaluation of the PNS disease. This is the basis for the concept of FESS. Material and Method: Patients attending ENT OPD in RIMS, Ranchi with any sino-nasal complains lasting for more than 4 weeks and not responding to...

OBJECTIVE The aims of our study were to verify the validity of the T-Scan III system (Tekscan) as an objective occlusal evaluation tool, and to assess the differences between two occlusal indexes-the peer assessment rating (PAR) index and the American Board of Orthodontics objective grading system (OGS)-by comparing the scores derived from the T-Scan III system with the two occlusal indexes and...

OBJECTIVES To determine the prevalence of oropharyngeal dysphagia (OPD) and its subtypes (oral phase, pharyngeal phase, saliva control), and their relationship to gross motor functional skills in preschool children with cerebral palsy (CP). It was hypothesized that OPD would be present across all gross motor severity levels, and children with more severe gross motor function would have increase...

PURPOSE Corneal collagen cross-linking (CXL) is a treatment strategy used in keratoconic eyes. Evaluation of long-term changes of higher-order aberrations (HOAs) after CXL is useful in understanding the efficacy of this procedure in improving optical, refractive, and visual acuity. This study aims to investigate the long-term effect of CXL on ocular HOA in patients with progressive keratoconus ...

Thirty male adult Wistar rats (300-/+10 g body weight) underwent either 5/6 nephrectomy (Nx, n=20) or sham operation (SHAM, n=10) to determine olpadronate effects in an experimental model of uremic bone disease. For a 38-day period, 10 rats received olpadronate (16microg/100g bw) once a week (Nx+OPD) and the other vehicle (Nx). SHAM received vehicle. At baseline, treatment onset (t=7 days) and ...

Large stellar telescope is indispensable for astronomy. Aperture synthesis is a well-known technique to simulate a large space telescope by an array of small telescopes. Condition for aperture synthesis is that the light of the telescopes have to be combined coherently. Therefore, an interferometric Fringe Sensor (FS) to detect and stabilize the Optical Path Difference (OPD) between light from ...

PURPOSE To study the effects of ocular lubricants on higher order aberrations in normal and self-diagnosed dry eyes. METHODS Unpreserved hypromellose drops, Tears Again™ liposome spray and a combination of both were administered to the right eye of 24 normal and 24 dry eye subjects following classification according to a 5 point questionnaire. Total ocular higher order aberrations, coma, sphe...