The capacity for spontaneous remyelination in cases of multiple sclerosis (MS) is limited and lesions are not fully repaired. Recent evidence has shown that oligodendrocyte precursor cells and immature oligodendrocytes (OPC/iOligs) are preserved in MS lesions. Induced differentiation of these cells into myelinating cells may ultimately lead to a novel remyelination therapy. A previous study sho...

BACKGROUND The incidence of oropharyngeal cancer (OPC) and a subset of oral cavity cancer (OCC) is increasing in the United States. To the authors' knowledge, the presumed growing prevalence of survivors of OPC and OCC has not been investigated to date. METHODS Retrospective analysis of Surveillance, Epidemiology, and End Results data (1975-2012) estimated changes in incidence, 5-year cause-s...

OPC-18790 is a vesnarinone analog currently in clinical trials for treatment of heart failure. In vitro studies have shown that, in addition to its positive inotropic actions, OPC-18790 prolongs cardiac action potentials. Therefore, in this study, the effects of OPC-18790 on cardiac potassium currents were compared with those we previously observed for the blockers quinidine and dofetilide in t...

Oropharyngeal candidiasis (OPC), caused by the commensal fungus Candida albicans, is an opportunistic infection associated with infancy, AIDS, and IL-17-related primary immunodeficiencies. The Th17-associated cytokines IL-23 and IL-17 are crucial for immunity to OPC, but the mechanisms by which they mediate immunity are poorly defined. IL-17RA-deficient humans and mice are strongly susceptible ...

Cilostazol (OPC-13013; 6-[4-(1-cyclohexl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone) is widely used as an antiplatelet vasodilator agent. In vitro, the hydroxylation of the quinone moiety of cilostazol to OPC-13326 [6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-4-hydroxy-2(1H)-quinolinone], is the predominant route, and the hydroxylation of the hexane moiety to OPC-13217 i...

This is the third and final article in our series about oral and pharyngeal cancer (OPC) in Florida1, 2 for Today’s FDA. This article adds to the literature by examining and reporting on survival rates of OPC by geographic regions in Florida and identifies a group with poor survival. We also highlight the results of a targeted media campaign that was designed to increase OPC examinations among ...

Sigma and 5-HT(1A) receptor stimulation can increase acetylcholine (ACh) release in the brain. Because ACh release facilitates learning and memory, we evaluated the degree to which OPC-14523 (1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2[1H]-quinolinone monomethane sulfonate), a novel sigma and 5-HT(1A) receptor agonist, can augment ACh release and improve learning impa...

This paper presents a comparative study on the effects of high temperature (~500°C) on carbonated calcium silicate-based cement (CSC), hydrated ordinary Portland cement (OPC), and hydrated OPC with 20% fly ash (FA) paste samples. The CSC is primarily composed of calcium–silicate minerals with different calcium to silica atomic ratios, such as wollastonite, rankinite, and pseudowollastonite. The...

Today, normally MES (Manufacturing execution systems) are isolated applications. Tomorrow, they have to be linked to each other. The prototypical engineeringframework based on OPC-UA (OLE for Process controlUnified architecture) processes data in the standardized XML-based format CAEX (Computer Aided Engineering Exchange) describing production plants. It configures MES and generates correspondi...

Interoperability in all the levels of a communication architecture for automation applications cannot be easily satisfied because control devices are generally based on different technologies and communication protocols. This paper deals with the interoperability of a well-known communication standard for home and building automation, i.e. the KNX. Current literature presents several papers dem...