نتایج جستجو برای: oncolysis
تعداد نتایج: 455 فیلتر نتایج به سال:
New treatments, such as gene therapy, are necessary for advanced gallbladder cancer (GBC), but little has been studied. Recent studies have introduced mutant adenoviruses (Ads) with either defective E1B-55kD or mutated E1A, focusing on tumor-specific replication, and the results have been promising. To enhance the safety of this approach, we constructed AxdAdB-3, a double-restricted Ad with a m...
We have shown previously the oncolytic potential of myxoma virus in a murine xenograft model of human glioma. Here, we show that myxoma virus used alone or in combination with rapamycin is effective and safe when used in experimental models of medulloblastoma in vitro and in vivo. Nine of 10 medulloblastoma cell lines tested were susceptible to lethal myxoma virus infection, and pretreatment of...
Abstract BACKGROUND Malignant paediatric nervous system tumours, such as medulloblastoma, ATRT and high-risk neuroblastoma commonly harbour tumour cells with stem-like features which are highly tumorigenic resistant to conventional therapies. These tumours can exhibit high lethality may result in severe sequelae that significantly affect patients' quality of life. Oncolytic virotherapy exploits...
The therapeutic efficacy of oncolytic viruses including adenovirus has been thought to depend mostly on direct viral destruction of tumor cells. However, this view has changed with the discovery that oncolysis can also induce innate and antigen-specific adaptive immunity against the tumor. Here we summarize our findings from cancer patients.
Intravenously injected spores of a number of species of nonpathogenic clostridia localized and germinated in tumor tissue but not in normal tissues of the mouse. In tumors of sufficient size liquefaction of an apparently substantial amount of viable tumor tissue occurred leading to statistically significant reduction of tumor weight in treated animals. Conditions for the quantitative measuremen...
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