Carcinogenesis is a multistep process and multifactorial disease. It is estimated that in developing countries upto 25% of tumours are associated with various microbes. Microbial carcinogenesis is a major public health problem. Viruses are now accepted as bonafide aetiologic factors of human cancer. A formidable level of evidence has determined that there exists a relationship between certain b...

Seven kinds of virus collectively comprise an important cause of cancer, particularly in less developed countries and for people with damaged immune systems. Discovered over the past 54 years, most of these viruses are common infections of humankind for which malignancy is a rare consequence. Various cofactors affect the complex interaction between virus and host and the likelihood of cancer em...

In view of the increasing evidence suggesting that human Cancer cells contain molecular footprints related to murine and primate type-C RNA tumor viruses (1-7), it is appropriate in this symposium to discuss a simple scheme for the life cycle of RNA tumor viruses. It is hoped that this scheme will be useful in searching for virus related proteins, nucleic acids and particulates in human leukemi...

Ubiquitination is one of the most important post-translational modifications of proteins with a profound effect on their intracellular stability and activity. Deubiquitinases (DUBs), on the other hand, act by removing the ubiquitin moiety from proteins and thereby reverse their stability and/or activity. Besides, DUBs play a major role in maintenance of free ubiquitin pool, histone modification...