The folding mechanism of outer membrane proteins (OMPs) of Gram-negative bacteria into lipid bilayers has been studied using OmpA of E. coli and FomA of F. nucleatum as examples. Both, OmpA and FomA are soluble in unfolded form in urea and insert and fold into phospholipid bilayers upon strong dilution of the denaturant urea. OmpA is a structural protein and forms a small ion channel, composed ...

Serotype B of Pasteurella multocida is a major agent of haemorrhagic septicaemia (HS), a form of blood poisoning widespread in cattle and buffalo from Southern Asia. The vaccines currently used against the disease are not potent enough, being effective only for a limited duration only. In an attempt to identify immunogenic components of P. multocida for use as live/subunit vaccines, the outer m...

β-Barrel outer membrane proteins (OMPs) are found in the outer membranes of Gram-negative bacteria and are essential for nutrient import, signaling, and adhesion. A 200-kilodalton five-component complex called the β-barrel assembly machinery (BAM) complex has been implicated in the biogenesis of OMPs. We report the structure of the BAM complex from Escherichia coli, revealing that binding of Ba...

BACKGROUND Outer membrane proteins (OMPs) constitute the main structure and about half of the cell wall of Gram-negative bacteria. The OMPs of Escherichia coli (E. coli) play an important role in its drug resistance. Previous studies have shown that the OMPs of E. coli enhance its pathogenic effects by helping the bacterium to evade the immune defense and promote its adsorption to host cells. W...

One framework type of high-silica zeolite only can effectively remove a limited range organic micropollutants (OMPs) from water. In order to extend the OMP removal range, different types zeolites need be combined in adsorption process. this study, Mordernite (MOR) and ZSM-5 (MFI) powders were mixed mass ratios. The performances eight OMPs by mixtures, as well single MOR MFI zeolites, evaluated ...

Pathogenic spirochetes are the causative agents of several important diseases including syphilis, Lyme disease, leptospirosis, swine dysentery, periodontal disease and some forms of relapsing fever. Spirochetal bacteria possess two membranes and the proteins present in the outer membrane are at the site of interaction with host tissue and the immune system. This review describes the current kno...

In Escherichia coli, the σ(E) transcription factor monitors and maintains outer membrane (OM) integrity by activating genes required for assembly of its two key components, outer membrane proteins (OMPs) and lipopolysaccharide (LPS) and by transcribing small RNAs to down-regulate excess unassembled OMPs. σ(E) activity is governed by the rate of degradation of its membrane-spanning anti-σ factor...

Proteins responsible for outer membrane transport across the unique membrane structure of Mycobacterium spp. are attractive drug targets in the treatment of human diseases caused by the mycobacterial pathogens, Mycobacterium tuberculosis, M. bovis, M. leprae and M. ulcerans. In contrast with Escherichia coli, relatively few outer-membrane proteins (OMPs) have been identified in Mycobacterium sp...

Abstract. A scientific total ozone column product from Ozone Mapping and Profiler Suite Nadir Mapper (OMPS-NM) observations the retrieval algorithm are presented. The employs weighting function fitting approach (WFFA), a modification of differential optical absorption spectroscopy (WFDOAS) technique. columns retrieved with WFFA in very good agreement other datasets. mean difference 0.3 % respec...

The outer membrane is a continuous structure on the surface of Gram-negative bacteria and has particular significance as one of the potential targets for protective immunity. Recent studies have focused attention on the outer membrane proteins (OMPs) suggesting the existence of protective immunogenic components in Salmonella. Outer membrane protein (OMPs) has been reported to be immunogens for ...