نتایج جستجو برای: oligonucleotides
تعداد نتایج: 12178 فیلتر نتایج به سال:
We present a novel method for fabricating unimolecular double-stranded DNA microarrays on solid surfaces, which were used to probe sequence-specific DNA/protein interactions. For manufacturing the unimolecular double-stranded DNA microarrays, two kinds of special single-stranded oligonucleotides, constant oligonucleotide and target oligonucleotide, were chemically synthesized. The constant olig...
RNA oligonucleotides have emerged as a new class of biologicals that can silence gene expression but also stimulate immune responses through specific pattern-recognition receptors. The development of effective delivery systems remains a major challenge for the therapeutic application of the RNA oligonucleotides. In this study, we have established a novel biodegradable carrier system that is hig...
Monocytes are important target cells for anti-inflammatory antisense strategies. However, monocytes are characterized by strong phagocytic and catalytic activity which may limit the effect of antisense oligonucleotides. Intracellular distribution of oligonucleotides in monocytes and the effect of cationic lipids on oligonucleotide uptake in monocytes and other leukocytes have not been evaluated...
Here it was investigated how oligonucleotide retention and selectivity factors are affected by electrostatic non-electrostatic interactions in ion pair chromatography. A framework derived describing depends on the potential generated ion-pair reagent concentration, co-solvent volume fraction, charge difference between analytes, temperature. Isocratic experiments verified that, separation proble...
In an article published by Helvetica Chimica Acta in 1995, chemist P. Martin describes the synthesis of 2?-O-alkylated ribonucleosides for use therapeutic antisense oligonucleotides (ASOs). This work was motivated need a modified ribose structure that compatible with solid-phase protocols and that, when incorporated into oligonucleotide, would render it resistant to nucleases without attenuatin...
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