نتایج جستجو برای: ohdg
تعداد نتایج: 950 فیلتر نتایج به سال:
Some selected oxidative stress parameters were measured in 56 Fanconi anaemia (FA) patients (42 untransplanted and 14 transplanted), 54 FA heterozygotes (parents) and 173 controls. Untransplanted FA patients showed a highly significant increase in leukocyte 8-hydroxy-2'-deoxyguanosine (8-OHdG) (P = 0.00003) and a borderline increase (P = 0.076) in urinary levels of 8-OHdG versus child controls....
12-O-Tetradecanoylphorbol.13-acetate (TPA)-mediated oxidative stress in HeLa cells and its inhibition were studied by fluorometric measurement of H2Oz and by 3H-postlabeling of the oxidized bases 8-hydroxyl-2'-deoxyguanosine (8-OHdG) and 5-hydroxymethyl-2'-deoxyuridine (HMdU). TPA treatment (10 fmol/cell) caused "~7-fold increase in H202 levels (0.1 nmol TPA/ml), and 5-10-fold increase in 8-OHd...
BACKGROUND Oxidative damage and DNA repair dysfunction are associated with carcinogenesis. 8-OHdG is one of the major oxidative DNA adducts. Present work aims to investigate whether the expression of 8-OHdG and its key repair gene hOGG1 play distinctive role in two types of serous ovarian cancer. MATERIALS AND METHODS 8-OHdG level in DNA from tumor and matched tumor-adjacent normal tissue in ...
OBJECTIVE The aim of this study was to investigate whether cortisol and oxidative stress levels and DNA damage differ between individuals who developed PTSD or not following a sexual trauma. METHODS The study included 61 children aged between 5 and 17 years who sustained sexual abuse (M/F: 18/43). The patients were divided into two groups: patients with PTSD and patients without PTSD based, b...
The aim of this study was to examine the associations between the combined effects of urinary 8-Hydroxydeoxyguanine (8-OHdG) level and polymorphisms of XRCC1 Arg194Trp and XRCC1 Arg399Gln on the risk of urothelial carcinoma (UC). We conducted a hospital-based case-control study that included 168 cases of UC and 336 age- and gender-matched healthy controls. We used polymerase chain reaction and ...
BACKGROUND Recently, we reported that urinary 8-hydroxy-2'-deoxyguanosine (U-8-OHdG), an oxidative stress marker, reflected inflammatory activity in cardiac sarcoidosis (CS). Here, we investigated whether U-8-OHdG levels were associated with ventricular tachycardia (VT) in patients with CS. METHODS AND RESULTS This prospective cohort study enrolled 62 consecutive patients with CS, of whom 36 ...
Purpose Although previous studies have investigated oxidative stress biomarkers in association with depression in non-stroke subjects, the association between oxidative deoxyribonucleic acid damage and post-stroke depression (PSD) remains unelucidated. Patients and methods Two hundred forty-one first-ever ischemic stroke patients were consecutively recruited within the first 24 h of stroke on...
Background. Oxidative stress is increasingly important in health research. Therefore, it is necessary to understand which factors determine basal oxidative stress. This study examines the associations of various determinants with markers of oxidative DNA and lipid damage: 8-hydroxy-2'-deoxyguanosine (8-OHdG) and F2-isoprostanes. Methods. Data are from the Netherlands Study of Depression and Anx...
مقدمه: شایع‌ترین علت ایسکمی‌میوکارد، آترواسکلروز است که می‌تواند منجر به انفارکتوس حاد قلبی شود. با توجه به اینکه در بیماران مبتلا به انفارکتوس حاد قلبی، سطح استرس اکسیداتیو بالا می‌رود، هدف از انجام این مطالعه بررسی میزان آسیب به DNA و ارزیابی سطح پروتئین شوک حرارتی 27HSP در این بیماران بود. مواد و روش‌ها: در این مطالعه‌ی مورد ـ شاهدی، 30 بیمار با تشخیص انفارکتوس حاد قلبی مورد بررسی قرار گرفت...
We describe the electrochemical determination of oxidative damaged DNA by using a nanocarbon film electrode combined with a high performance liquid chromatography (HPLC) system. The nanocarbon film was formed by employing the electron cyclotron resonance sputtering method, and has a nano-crystalline sp(2) and sp(3) mixed bond structure with an atomically flat surface. This film electrode provid...
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