نتایج جستجو برای: odorant

تعداد نتایج: 3893  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
Timothy S McClintock Kaylin Adipietro William B Titlow Patrick Breheny Andreas Walz Peter Mombaerts Hiroaki Matsunami

Our understanding of mammalian olfactory coding has been impeded by the paucity of information about the odorant receptors (ORs) that respond to a given odorant ligand in awake, freely behaving animals. Identifying the ORs that respond in vivo to a given odorant ligand from among the ∼1100 ORs in mice is intrinsically challenging but critical for our understanding of olfactory coding at the per...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1998
B J Doleman E J Severin N S Lewis

Response data were collected for a carbon black-polymer composite electronic nose array during exposure to homologous series of alkanes and alcohols. The mean response intensity of the electronic nose detectors and the response intensity of the most strongly driven set of electronic nose detectors were essentially constant for members of a chemically homologous odorant series when the concentra...

2017
Andrea Degl’Innocenti Anna D’Errico

The odorant receptor genes, seven transmembrane receptor genes constituting the vastest mammalian gene multifamily, are expressed monogenically and monoallelicaly in each sensory neuron in the olfactory epithelium. This characteristic, often referred to as the one neuron-one receptor rule, is driven by mostly uncharacterized molecular dynamics, generally named odorant receptor gene choice. Much...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
Ayumi Nagashima Kazushige Touhara

Odor information is decoded by a combination of odorant receptors, and thus transformed into discrete spatial patterns of olfactory glomerular activity. It has been found, however, that for some odorants, there are differences between the ligand specificity of an odorant receptor in vitro and its corresponding glomerulus in vivo. These observations led us to hypothesize that there exist prerece...

2005
Michal R. Zochowski Lawrence B. Cohen Michal Zochowski

2 While odorant evoked oscillations in the vertebrate olfactory bulb have been studied extensively, information about their possible cognitive role has been missing. Using voltage sensitive dye imaging we show that repeated odorant presentations with interstimulus intervals of 2-12 seconds had dramatic and diverse effects on the three oscillations that occur in the turtle olfactory bulb. Two of...

Journal: :PloS one 2016
Anna Reese Nanna Holmgaard List Jacob Kongsted Ilia A Solov'yov

The biophysical mechanism of the sense of smell, or olfaction, is still highly debated. The mainstream explanation argues for a shape-based recognition of odorant molecules by olfactory receptors, while recent investigations suggest the primary olfactory event to be triggered by a vibrationally-assisted electron transfer reaction. We consider this controversy by studying the influence of a rece...

2014
Karine Audouze Anne Tromelin Anne Marie Le Bon Christine Belloir Rasmus Koefoed Petersen Karsten Kristiansen Søren Brunak Olivier Taboureau

The human olfactory system recognizes a broad spectrum of odorants using approximately 400 different olfactory receptors (hORs). Although significant improvements of heterologous expression systems used to study interactions between ORs and odorant molecules have been made, screening the olfactory repertoire of hORs remains a tremendous challenge. We therefore developed a chemical systems level...

2013
Swapnil Pravin Matthew A. Reidenbach

Crustaceans such as crabs, lobsters and crayfish use dispersing odorant molecules to determine the location of predators, prey, potential mates and habitat. Odorant molecules diffuse in turbulent flows and are sensed by the olfactory organs of these animals, often using a flicking motion of their antennules. These antennules contain both chemosensory and mechanosensory sensilla, which enable th...

2005
Michele L. Rankin Richard Bruch Steve Finckbeiner Jim Parker Shane Rolen Margaret Pace Brian Hoffpauir Kyle Waite Patricia Arbour-Reily Beth Floyd Cindy Henk Ron Bouchard

Olfactory signal transduction is initiated by binding of odorous ligands to G proteincoupled odorant receptors, resulting in the activation of G protein and second messengers that culminates in the generation of action potentials to relay this signal to the brain for odor recognition. This signaling cascade comprises the primary olfactory response. Odorant receptors comprise the largest multige...

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