abstract introduction. p53 has been known as a tumor suppressor gene and also ki-67 is a cell cycle regulator. the aim of present study was to investigate p53 and ki-67 protein expression in the epithelial lining of odontogenic cysts and its correlation with their biologic behavior and the degree of inflammation within the cyst wall. methods. p53 and ki-67 immunoreactivity in 58 odontogenic cys...

A case of central carcinoma of the mandible arising from a recurrent odontogenic keratocyst is reported. A 38-year-old man was admitted to the Tokai University Hospital due to postoperative infection of a recurrent odontogenic keratocyst of the left mandible. He had had a cystectomy for an odontogenic keratocyst 4 years ago. The lesion revealed bony destruction of the mandible with worm-eating ...

Objective: To assess the thickness and color of collagen fibres in various odontogenic cysts for its possible role in expansion. Study design: 49 cases of 4 types of odontogenic cysts and 5 normal mucosal tissues were selected as the study and the control group respectively. All slides were stained with both Hemotoxylin and Eosin and the picrosirius red stain. The thickness of collagen fibres w...

Carnoy’s solution was first used as a medicament in surgery by Cutler and Zollinger in 1933. The reformulated carnoy’s solution without chloroform is accepted because exposure to chloroform has been associated with cancer and reproductive toxicity. It is assumed that carnoy’s solution eradicates epithelial rests from the cyst wall and reduces the rate of recurrence. In the world health organiza...

Sir, Odontogenic keratocyst (OKC) is known for its pathognomonic features, i.e., aggressiveness and high rates of recurrence, which has been of interest and debate since the first description of this entity by Philipsen in 1956.[1] Recently, the World Health Organization (WHO) working group on odontogenic tumors recommended the term “Keratocystic Odontogenic Tumors” (KCOT) for these lesions to ...

Since the term odontogenic keratocyst first appeared in the literature, controversy has surrounded its terminology and surgical management. Recent articles would suggest that surgical opinion is still divided between aggressive radical resection and a more conservative approach. We present an interesting case of a large keratocystic odontogenic tumour shown to have eroded through bony cortices ...

actinomycosis is an anaerobic infection that involves the craniofacial region and its colonization has rarely been reported in the developmental odontogenic cysts. in the present report, a case of odontogenic keratocyst (which is now called keratocystic odontogenic tumor) with the colonization of actinomyces is introduced and its significance is discussed.

Verrucous proliferation arising from odontogenic cysts is a rare entity. We report an unusual case of an infected odontogenic cyst with verrucous proliferation and melanin pigmentation in a 13-year-old male patient who presented with an intraoral swelling in relation to impacted teeth 26 and 27. The enucleated lesion was diagnosed as an odontogenic keratocyst and the patient died within two yea...

The lesion traditionally known as odontogenic keratocyst has been renamed by WHO in 2005, as “keratocystic odontogenic tumor” as it is more appropriate and reflects its potential for local, destructive behavior. It is a benign intraosseous neoplasm of jaw, which is unusual due to its characteristic histopathological and clinical features, including potentially aggressive behavior, high recurren...