PURPOSE Conventional ophthalmic systems present very low corneal systemic bioavailability due to the nasolacrimal drainage and the difficulty to deliver the drug in the posterior segment of ocular tissue. For these reasons, recent advances have focused on the development of new ophthalmic drug delivery systems. This review provides an insight into the various constraints associated with ocular ...

An eye is the most precious and easily accessible organ of the body. It possesses easy route to local drug delivery and is a way to non-invasive clinical treatment of ocular diseases. Ocular delivery in spite of possessing various advantages has the limitation of poor bioavailability and low permeability across the cornea thus, limiting the efficacy of drugs. Therefore, various carrier systems ...

In order to achieve prolong corneal contact time of norfloxacin(NFX) for treatment of extra ocular diseases, a pH triggered nanoparticulate in situ gelling system was designed to explore dual advantage of nanoparticles and in situ gelling system, for its ocular delivery. NFX loaded nanocarriers were developed by ionotropic gelation technique using chitosan as a matrix forming polymer, cross-lin...

In order to achieve prolong corneal contact time of norfloxacin(NFX) for treatment of extra ocular diseases, a pH triggered nanoparticulate in situ gelling system was designed to explore dual advantage of nanoparticles and in situ gelling system, for its ocular delivery. NFX loaded nanocarriers were developed by ionotropic gelation technique using chitosan as a matrix forming polymer, cross-lin...

Oküler ilaç uygulamaları, gözün yapısal karmaşıklığı ve savunma mekanizmaları nedeniyle oftalmologlar oküler taşıyıcı sistemler üzerine çalışan bilim insanları için çok zorlu bir alandır. Farklı kornea katmanları, sklera, konjonktival kan akışı, gözyaşı seyreltmesi retina bariyeri gibi engeller, anterior posterior kısımlarına uygulanması etkinliğini sınırlamaktadır. Konvansiyonel uygulama şekil...

Drug delivery in ocular therapeutics is a challenging problem and is a subject of interest to scientists working in the multidisciplinary areas pertaining to the eye. Most ocular diseases are treated by topical drug application in the form of solutions, suspensions and ointment. These conventional dosage forms suffer from the problems of poor ocular bioavailability, because of various anatomica...