Leptin acts as a modulator of diverse reproductive functions, and recent studies have implicated involvement of leptin in the early embryo development in mammal. The aim of this study was to investigate the expression of leptin and its receptor (OB-R) in mouse oocyte and preimplantation embryo, and to examine whether leptin influenced the early embryo development. Leptin mRNA was detected in bl...

A G ir l N am ed D ig it b y A nn ab el M on ag ha n Y ou ng A du lt F ic ti on /E sp io na ge H ou gh to n M if fl in , 20 12 , 18 7 pp ., $ 16 .9 9 IS B N : 97 8054 766 85 29 Fa rr ah H ig gi ns h as a s ec re t. S he s ee m s lik e yo ur a ve ra ge t ee na ge r, b ut s he ’s a ct ua lly D ig it , m at h ge ni us e xt ra or di na ir e. W he n he r su pe rs on ic b ra in b ec am e a pr ob le m...

Methotrexat stellt nach wie vor das bevorzugte Erstlinientherapeutikum für Patientinnen und Patienten mit einer rheumatoiden Arthritis (RA) dar. Allerdings sprechen bis zu 40% der Betroffenen nicht auf den Wirkstoff an mehr als 50% beendeten die Therapie innerhalb von 3 5 Jahren. Ein internationales Forscherteam prüfte nun, ob sich Therapieansprechen mithilfe eines Algorithmus Basis Maschinenle...

Leptin, the 16-kDa peptide hormone product of the ob gene, is produced primarily by adipocytes and was initially thought to exert its effects exclusively through actions on the hypothalamus via distinct leptin receptors termed OB-R. However, recent data show that leptin is produced elsewhere and that receptors are present in many other tissues. Using real-time PCR, we determined whether leptin ...

Obesity is an important risk factor for asthma. We recently reported increased ozone (O(3))-induced hyperresponsiveness to methacholine in obese mice (Shore SA, Rivera-Sanchez YM, Schwartzman IN, and Johnston RA. J Appl Physiol 95: 938-945, 2003). The purpose of this study was to determine whether this increased hyperresponsiveness is the result of changes in the airways, the lung tissue, or bo...

The ob gene product, leptin, is produced predominantly in adipose tissue. In ob/ob mice, a mutation in the ob gene prevents normal leptin production and results in a phenotype characterized by obesity and diabetes (Zhang et al. 1994). Daily injections of recombinant leptin to ob/ob mice inhibit food intake and reduce body weight and fat mass (Campfield et al. 1995; Halaas et al. 1995; Pelleymou...

Recent studies have suggested that leptin hormone may play a pivotal role on bone remodeling through a direct effect by modulating positively the OPG/RANKL balance. Here, we investigate the effect of leptin hormone on RANKL and OPG expression in MC3T3-E1 osteoblasts using RT-PCR and ELISA measurements. We have at first identified the expression of Ob-Rb and Ob-Ra leptin receptor isoforms in MC3...

A method of " l ea rn ing from observat ion" la presented which s t ruc tu res a c o l l e c t i o n of ob jecta i n t o h ie ra rch ies of subcategor ies, such tha t each subcategory la character ised by a con junct ive d e s c r i p t i o n i nvo l v i ng r e l a t i o n s on selected ob ject a t t r i b u t e s . The conjunct ive descr ip t ions sprout ing from each node are mutual ly d i s ...