BACKGROUND AND PURPOSE Preadmission oral anticoagulant treatment (OAT) has been linked with less severe stroke and a better outcome in patients with atrial fibrillation. However, the existing studies have methodological limitations and have, with one exception, not included hemorrhagic strokes. We performed a nationwide historic follow-up study using data from population-based healthcare regist...

BACKGROUND Substance use and substance use disorders are common in people who experience detention or incarceration in Canada, and opioid agonist treatment (OAT) may reduce the harms associated with substance use disorders. We aimed to define current physician practice in provincial correctional facilities in Ontario with respect to prescribing OAT and to identify potential barriers and facilit...

Hulless oats are of interest as an alternative to corn and wheat in organic poultry diets because they offer potential to enhance agrobiodiversity and produce locally grown feeds both within and outside of corn-growing regions. Hulless oats are easily certified GM-free and have demonstrated nutritional value for poultry. A feeding study was carried out to examine: (i) the effects of substitutin...

PURPOSE To evaluate the efficacy of adenovirus mediated transfer of ornithine delta-aminotransferase (OAT) into human retinal pigment epithelial (RPE) cells. METHODS Adenovirus-mediated gene transfer into primary cultures of human RPE was evaluated by measurement of enzyme activity in whole cell extracts and by Western blot analysis. To assess mitochondrial integrity, succinate dehydrogenase ...

The aim of the study is to evaluate effect Oat–field pea intercropping on yield, nutritive value, and environmental impact oat grown under a reduced level nitrogen fertilisation. trial was laid out in randomized complete block design with following treatments: oat-0 (oat (Avena sativa L., SRCP X 80 Ab 2291 variety) without N fertilization (urea)), oat-23 fertilised 23 kg N/ha), oat-46 46 O1P1 i...

A study was initiated in 2001at four locations in western Canada to investigate an integrated approach to managing wild oat, the region’s worst weed. The study examined the effects of combining semidwarf or tall barley cultivars with normal or twice-normal barley seeding rates in either continuous barley or a barley–canola–barley–field pea–barley rotation. Herbicides were applied at 25, 50, and...

Viral determinants involved in systemic infection of hosts by monocot-infecting plant viruses are poorly understood. Wheat streak mosaic virus (WSMV, genus Tritimovirus, family Potyviridae) exclusively infects monocotyledonous crops such as wheat, oat, barley, maize, triticale, and rye. Previously, we reported that WSMV CP amino acids 36-84 are expendable for systemic infection of wheat, maize,...

We recently cloned and characterized the rat kidney-specific organic anion transporter, OAT-K1, which was suggested to mediate renal tubular transport of methotrexate. In this study, we investigated the interactions of nonsteroidal anti-inflammatory drugs (NSAIDs) with OAT-K1 by evaluating the effects of these drugs on renal distribution of methotrexate in vivo, and on methotrexate accumulation...

BACKGROUND AND PURPOSE In patients with atrial fibrillation (AF), oral anticoagulant therapy (OAT) is effective in reducing stroke and embolism. However, despite OAT, ischemic events do occur in some patients. Studies specifically addressing the identification of risk factors for ischemic events during well-conducted OAT are not available. In this study, we prospectively investigated the role o...