The extent of hyperthermophilic microbial diversity associated with siliceous sinter (geyserite) was characterized in seven near-boiling silica-depositing springs throughout Yellowstone National Park using environmental PCR amplification of small-subunit rRNA genes (SSU rDNA), large-subunit rDNA, and the internal transcribed spacer (ITS). We found that Thermocrinis ruber, a member of the order ...

We present a new planktonic foraminifera model developed for the global ocean mixed-layer. The main purpose of the model is to explore the response of planktonic foraminifera to different boundary conditions in the geological past, and to quantify the seasonal bias in foraminiferabased paleoceanographic proxy records. This model is forced with hydrographic data and with biological information t...

Protein-solvent interactions govern the behaviors of proteins isolated from extreme halophiles. In this work, we compared the solvent envelopes of two orthologous tetrameric malate dehydrogenases (MalDHs) from halophilic and non-halophilic bacteria. The crystal structure of the MalDH from the non-halophilic bacterium Chloroflexus aurantiacus (Ca MalDH) solved, de novo, at 1.7 Å resolution exhib...

The aim of this study was to determine the expression intensity of PCNA and Ki-67 tissue antigens related to pathologically modified oral mucosa in OLR lesions, and to determine the reaction intensity of these antigens in individual clinical forms, i.e. lichen ruber planus (LRP) and lichen ruber erosivus (LRE) comparing the reaction intensity with the inflammation grade and the degree of hyperk...

Sir: In previous papers from our laboratory, ML236B, a metabolite of Penicillium citrinum that was isolated as an inhibitor of cholesterol synthesis1), was shown to have hypocholesterolemic activity in several animal species2,3). Further work in this laboratory to search for microbial metabolites having cholesterol-lowering activity led to the isolation of a new active compound (designated as m...

Talaromyces emersonii, a thermophilic aerobic fungus, produces a complete xylan-degrading enzyme system when grown on appropriate substrates. In this paper we present the physicochemical and catalytic properties of three enzymes, xylosidase (Xyl) I (M(r) 181,000; pI 8.9), II (M(r) 131,000; pI 5.3) and III (M(r) 54,200; pI 4.2). Xyl I and II appear to be dimeric and Xyl III is a single-subunit p...

764 Ann Dermatol Received October 4, 2013, Revised October 31, 2013, Accepted for publication November 7, 2013 Corresponding author: Sang Ho Oh, Department of Dermatology, Cutaneous Biology Research Institute, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea. Tel: 82-2-2228-2080, Fax: 82-2-393-9157, E-mail: [email protected] This is an Open Access article d...

tiydroxylation of monacolin L to monacolin J by M. ruberlt8). The present communication deals with the transformation of monacolin J to monacolin K by a cell-free extract of M. ruber and by living cells of Paecilomyces viridis. The latter fungus is known to produce compactin (ML-236B) analogs, another family of HMG-CoAreductase inhibitors6). M. ruber M4681 was grown aerobically in a medium cont...