Recent neurochemical results suggest the hypothesis that the nucleus basalis magnocellularis (nbm) cholinergic projection to the amygdala may play a role in memory. The present study investigated the effects of intra-amygdaloid injections of the cholinergic antagonist scopolamine on working and reference memory in the double Y-maze. Rats were pretrained until working and reference memory choice...

Maze performance and morphology of frontal cortex were assessed in young adult, middle-aged, and aged rats with and without lesions of the nucleus basalis magnocellularis. Although maze performance did not vary with age, neuron number and the thickness of superficial laminae were reduced in aged rats. Lamina II-III neurons were hypertrophied in middle-aged rats relative to both younger and olde...

Phosphatidylinositol metabolism, linked to muscarinic receptor activation, was studied in rat cortical slices after a unilateral quinolinic acid lesion to the nucleus basalis magnocellularis (nbM) or the cortex itself. The incorporation of [3H]inositol into inositol phosphate was measured in the presence of LiCl, followed by anion exchange chromatography to separate inositol phosphates. Carbach...

In this study, we proposed that administration of hippocampal growth hormone in ageing animals with growth hormone deficiency can compensate long-term potentiation and synaptic plasticity in nucleus basalis magnocellularis (NBM)-lesioned rats. Aged male Wistar rats were randomly divided into six groups (seven in each) of sham-operated healthy rats (Cont); NBM-lesioned rats (L); NBM-lesioned rat...

Experiment 1 examined the effects of electrical stimulation of nucleus basalis magnocellularis (NBM) on a relational odor-association task--the social transmission of food preference (STFP). Rats were stimulated unilaterally in the NBM for 20 min (100 microA, 1 Hz) immediately before the social training. They were tested on their ability to remember preference for the trained food either immedi...

Functional dissociations between the medial septal area (MSA) and the nucleus basalis magnocellularis (NBM) were examined using the concepts and experimental procedures developed by scalar timing theory. Rats were tested in variations of a signalled discrete-trial peak-interval schedule of reinforcement in which the response rate functions identified the time when the rats expected reinforcemen...

The role of the nucleus basalis magnocellularis (NBM) in fear conditioning encoding is well established. In the present report, we investigate the involvement of the NBM histaminergic system in consolidating fear memories. The NBM was injected bilaterally with ligands of histaminergic receptors immediately after contextual fear conditioning. Histaminergic compounds, either alone or in combinati...

Introduction: Previous studies have shown that exercise enhances cognitive and functional capacities in patients with Alzheimer's disease (AD). In this study, we investigated the effect of long-term (60 days) and shortterm (10 days) exercise on the spatial memory deficits in an animal model of AD. Methods: Fifty male rats were divided into 5 groups; 1) intact, 2) sham, 3) sham-Alzheimer 4) Alzh...

AIM To investigate the primary electrophysiological and pharmacological properties of the nucleus basalis magnocellularis (nbM) neurons. METHODS Single unit extracellular recordings from the nbM neurons were obtained with glass micropipettes in urethane-anesthetized rats. RESULTS Most nbM neurons responded to noxious but not innocuous mechanical, thermal, chemical, and electrical stimuli. T...