نتایج جستجو برای: nucleostemin

تعداد نتایج: 191  

2015
Farinaz Nazmi Mohammad Amin Moosavi Marveh Rahmati Mohammad Ali Hoessinpour-Feizi

Human GNL3 (nucleostemin) is a recently discovered nucleolar protein with pivotal functions in maintaining genomic integrity and determining cell fates of various normal and cancerous stem cells. Recent reports suggest that targeting this GTP-binding protein may have therapeutic value in cancer. Although, sequence analyzing revealed that nucleostemin (NS) comprises 5 permuted GTP-binding motifs...

2015
Young Jeon Yong-Joon Park Hui Kyung Cho Hyun Ju Jung Tae-Kyu Ahn Hunseung Kang Hyun-Sook Pai

Nucleostemin is a nucleolar GTP-binding protein that is involved in stem cell proliferation, embryonic development, and ribosome biogenesis in mammals. Plant nucleostemin-like 1 (NSN1) plays a role in embryogenesis, and apical and floral meristem development. In this study, a nucleolar function of NSN1 in the regulation of ribosome biogenesis was identified. Green fluorescent protein (GFP)-fuse...

2013
Hamid Bayat Fardin Fathi Habibollah Peyrovi Seyed Javad Mowla

OBJECTIVE Endothelial progenitor cells (EPCs) have a potential application for cell therapy, however, their biological nature is not well-understood. EPCs also possess some stemness features, such as their clonogenicity and differentiation capacity. The main aim of this study was to evaluate the expression of certain transcription factors regulating selfrenewal property of stem cells. MATERIA...

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