BACKGROUND Human induced pluripotent stem cells offer perspectives for cell therapy and research models for diseases. We applied this approach to the normal and pathological erythroid differentiation model by establishing induced pluripotent stem cells from normal and homozygous sickle cell disease donors. DESIGN AND METHODS We addressed the question as to whether these cells can reach comple...

The effects of cell age on protein synthesis were examined in the nucleated red blood cells of rainbow trout (Oncorhynchus mykiss). Total DNA content was unaffected by cell age, whereas total RNA content in young red blood cells was roughly ten times as high as that in old red blood cells. The mRNA levels for haemoglobin, carbonic anhydrase and the chloride/bicarbonate (Cl(-)/HCO(3)(-)) exchang...

This study explored the changes in bone marrow CD235a+ nucleated red blood cell apoptosis and signal pathways patients with chronic mountain sickness. We collected data from 21 sickness 20 non-chronic patients. Bone mononuclear cells, flow cytometry is used to detect apoptotic index of cells determine mitochondrial membrane potential; reverse transcription quantitative polymerase chain reaction...

one of the most fundamental components of healthcare system on each country is blood supply chain management. this chain is comprised of two significant components including collecting donor’ bloods and supplying blood’s products. the main purpose of this paper is to concentrate on supplying blood products and present a novel constrained bi-objective mathematical model for a two-echelon blood s...

In general, there is a reversal of the normal in the ratio of clasmatocytes in the spleen to clasmatocytes in the bone marrow in pernicious anemia, with a marked tendency toward the phagocytosis of young, immature, nucleated red blood cells in the bone marrow. The peripheral blood picture suggests that these cells had never been in circulation. The observations made do not indicate that the spl...

The immediate and short term outcomes of term newborns with perinatal asphyxia were studied in relation to the nucleated red blood cell count at admission. The mean (SD) NRBC/100WBC (white blood cells) was significantly higher in sequelae group than normal [9.8 (98.9) vs. 2.9 (43); P=0.001].

The XE-2100 is a new automated hematology analyzer developed by Sysmex Corporation. With consideration of medical analyzer requirements for the 21st century, this unit was developed to satisfy the following concepts and to cope with diversified laboratory needs. 1) Electronic network communication 2) Presentation of high level value-added information 3) Contribution to test cost control 4) Purs...