The conserved NineTeen protein complex (NTC) is an integral subunit of the spliceosome and required for intron removal during pre-mRNA splicing. The complex associates with the spliceosome and participates in the regulation of conformational changes of core spliceosomal components, stabilizing RNA-RNA- as well as RNA-protein interactions. In addition, the NTC is involved in cell cycle checkpoin...

Malignant transformation is known to involve substantial rearrangement of the molecular genetic landscape of the cell. A common approach to analysis of these alterations is a reductionist one and consists of finding a compact set of differentially expressed genes or associated signaling pathways. However, due to intrinsic tumor heterogeneity and tissue specificity, biomarkers defined by a small...

OBJECTIVE To document the impact of changes to tobacco taxes on the range and price of tobacco sold during the period when the National Tobacco Campaign (NTC) was run. DATA SOURCES Information about brand availability, pack size, and price was extracted from Australian Retail Tobacconist. A retail observational survey was undertaken to monitor actual retail prices. Data on cigarette prices, b...

Exposure to traumatic stress is associated with increased risk for posttraumatic stress disorder (PTSD) and alterations of hypothalamic-pituitary-adrenocortical (HPA) function. Research linking traumatic stress with HPA function in PTSD has been inconsistent, however, in part due to (a) the inclusion of trauma-exposed individuals without PTSD (TE) in control groups and (b) a failure to consider...

Thermistors are very commonly used for narrow temperature-range high-resolution applications, such as in medicine, calorimetry, and near ambient temperature measurements. In particular, Negative Temperature Coefficient (NTC) thermistor is very inexpensive and highly sensitive, whose sensing temperature range and sensitivity are highly limited due to the intrinsic nonlinearity and self-heating p...

A new generation method to implement CMOS floating resistors is presented. The generation method depends on the linearization of the differential current of two matched NMOS transistors in two alternative configurations. The CMOS floating resistors implemented are based on using MOS transistors operating in the saturation region with their sources connected to their substrates. New CMOS floatin...

Title: DISTRESS TOLERANCE TREATMENT FOR INNER-CITY DRUG USERS: A PRELIMINARY TRIAL Marina Alexa Bornovalova, Ph.D., 2008 Directed By: Carl W. Lejuez, Associate Professor, Department of Psychology Despite advances in preventing treatment failure, a large percentage of substanceusing individuals drop out of treatment. Current work indicates that one’s threshold for tolerating psychological distre...

Integral nickel–phosphorus (NiP) resistors were fabricated on flexible polyimide (PI) substrates by electroless NiP deposition. The deposition process was first set up for standard rigid epoxy substrates and then modified for the flexible substrates. The effects of the PI surface modifications on the interfacial adhesion (NiP/PI) were measured experimentally by the pull-off method. The process ...

Experimental and numerical studies are conducted on the thermal, chemical and dilution effects of buffer gas composition on autoignition of dimethyl ether (DME). The buffer gases considered are nitrogen (N2), a mixture of N2 and argon (Ar) at a mole ratio of 50%/50% and a mixture of Ar and carbon dioxide (CO2) at a mole ratio of 61.2%/38.8%. Experiments are performed using a rapid compression m...

BACKGROUND Trauma centers (TCs) have been shown to decrease mortality in adults, but this has not been demonstrated at a population level in all children. We hypothesized that seriously injured children would have increased survival in a TC versus nontrauma center (nTC), but there would be no increased benefit from pediatric-designated versus adult TC care. METHODS This was a retrospective st...