Temporal changes in plant tissue non-structural carbohydrates (NSC) may be sensitive to climate changes that alter forest phenology. We examined how temporal fluctuations in tissue NSC concentrations of Populus grandidentata and Quercus rubra relate to net and gross primary production (NPP, GPP) and their climatic drivers in a deciduous forest of Michigan, USA. Tissue NSC concentrations were co...

Alzheimer's disease (AD) is a common case of dementia and its possible therapies, such as neuron stem cell (NSC) transplantation therapy, have been studied for years. In order to improve NSC transplantation effects, we were inspired to pretreat NSC using brain-derived neurotrophic factor (BDNF) before transplantation. The AD mouse model was constructed and effects of BDNF+NSC transplant group a...

This study delineated the incidence of metastatic involvement of neural stem cell (NSC) regions and further aimed to explore the feasibility of selectively sparing the NSC compartments during whole brain radiotherapy (WBRT) and prophylactic cranial irradiation (PCI). A total of 2270 intracranial metastases in 488 patients were identified. Lesions were classified according to locations, includin...

1. The embryonic neural stem cell (NSC) microenvironment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.1. The VZ microenvironment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.2. Signalling in the embryonic NSC microenvironment . . . . . . . . . . . . . . . . . . . . . . . . . . . ....

PURPOSE The CD52-targeted antibody alemtuzumab induces major clinical responses in a group of patients with myelodysplastic syndromes (MDS). The mechanism underlying this drug effect remains unknown. EXPERIMENTAL DESIGN We asked whether neoplastic stem cells (NSC) in patients with MDS (n = 29) or acute myelogenous leukemia (AML; n = 62) express CD52. RESULTS As assessed by flow cytometry, C...

In the adult brain, self-renewal is essential for the persistence of neural stem cells (NSCs) throughout life, but its regulation is still poorly understood. One NSC can give birth to two NSCs or one NSC and one transient progenitor. A correct balance is necessary for the maintenance of germinal areas, and understanding the molecular mechanisms underlying NSC division mode is clearly important....

Resistance to lodging, an important problem in rice production, has three types: low plant height, strong culm, and high strength of the lower part plant. The determinants remains unclear, compared with height culm strength. This study identified a new genetic factor involved part, as assessed by pushing resistance, using chromosomal segment substitution lines (CSSLs) clarify functional analysi...

BACKGROUND The aim of this study is to explore whether availability of sports facilities, parks, and neighbourhood social capital (NSC) and their interaction are associated with leisure time sports participation among Dutch adolescents. METHODS Cross-sectional analyses were conducted on complete data from the last wave of the YouRAction evaluation trial. Adolescents (n = 852) completed a ques...

Glutamate-induced excitotoxicity is a major contributor to motor neuron degeneration in the pathogenesis of amyotrophic lateral sclerosis (ALS). The spinal cord × Neuroblastoma hybrid cell line (NSC-34) is often used as a bona fide cellular model to investigate the physiopathological mechanisms of ALS. However, the physiological response of NSC-34 to glutamate remains insufficiently described. ...

Neural stem cells/neural progenitor cells (NSCs/NPCs) residing in the neurogenic regions of the brain play a crucial role in brain development, brain plasticity, and brain repair. Recent progress in NSC/NPC research has advanced our understanding of the NSC/NPC niche and signaling networks controlling NSC/ NPC proliferation and differentiation. However, the natural behavioral of NSCs/ NPCs in r...