Background: Bovine congestive heart failure (BCHF) has become increasingly prevalent among feedlot cattle in the Western Great Plains of North America with up to 7% mortality affected herds. BCHF is an untreatable complex condition involving pulmonary hypertension that culminates right ventricular and death. Genes associated have not been previously identified. Our a...

Nucleostemin 3 (NS3) is an evolutionarily conserved protein with profound roles in cell growth and viability. Here we analyze cell-autonomous and non-cell-autonomous growth control roles of NS3 in Drosophila and demonstrate its GTPase activity using genetic and biochemical assays. Two null alleles of ns3, and RNAi, demonstrate the necessity of NS3 for cell autonomous growth. A hypomorphic allel...

Background: Uncaria gambir is one Uncaria species that exclusively grows in Indonesia. The phytochemical constituents of this have been widely explored and its extracts are used as traditional medicine. However, the relationship between Uncaria gambir other still unknown. DNA barcoding was stu...

Background: When moved orthodontically, hypofunctional teeth will have a decreased tooth movement rate compared to normal teeth. Hypofunctional would less VEGF expression and heparan sulfate proteoglycan production during orthodontic movement. This study aimed determine the number of osteoblasts in tension side osteoclasts pressure Method: 18 mal...

Non-structural protein 3 (NS3) is a multifunctional enzyme possessing serine protease, NTPase, and RNA unwinding activities that are required for hepatitis C viral (HCV) replication. HCV non-structural protein 4A (NS4A) binds to the N-terminal NS3 protease domain to stimulate NS3 serine protease activity. In addition, the NS3 protease domain enhances the RNA binding, ATPase, and RNA unwinding a...

Mosquito-borne WNV (West Nile virus) is an emerging global threat. The NS3 proteinase, which is essential for the proteolytic processing of the viral polyprotein precursor, is a promising drug target. We have isolated and biochemically characterized the recombinant, highly active NS3 proteinase. We have determined that the NS3 proteinase functions in a manner that is distantly similar to furin ...

Persistent infections of hepatitis C virus (HCV) are known to be a major risk factor for causing hepatocellular carcinomas. Nonstructural protein 3 (NS3) of HCV has serine protease and RNA helicase domains, and is essential for the viral replication. Further, NS3 is also considered to be involved in the development of HCV-induced hepatocellular carcinomas. In this report, we focus on the functi...

Introduction: Grapsus albolineatus is thought to have a high concentration of carotenoid pigments. Although studies on male G. been conducted, no pigment extraction from female carried out. Carotenoids ability fight free radicals. Previous research has shown that carotenoids can radicals cause premature skin-aging. The purpose thi...

Hepatitis C virus (HCV) variation in specific T-cell epitopes may represent a mechanism of viral persistence in chronic infection. We examined the HCV non-structural protein 3 (NS3), including the immunologically relevant epitopes HCV NS3-2 KLVALGINAV (human leukocyte antigen [HLA]-A2-restricted) and HCV NS3-1391 LIFCHSKKK (HLA-A3-restricted), in 22 HLA-A2+ patients with chronic infection. Sign...

Background: Photo-electro-chemical (PEC) water splitting represents a promising technology towards an artificial photosynthetic device but many fundamental electronic processes, which govern long-term stability and energetics, are not yet fully understood. X-ray absorption spectroscopy (XAS), particularly its high energy resolution fluorescence-d...