The appearance of electrophoretically separable isozyme patterns is specific both to type of tissue and to its stage of development (Markert & Moller, 1959). In abnormally developing embryonic systems there are alterations in the time of initial appearance and the persistence of isozymes from a variety of metabolic areas (Johnson & Spinuzzi, 1966, 1968). In malformed embryos from folic-aciddefi...

The assay of serum enzymes has been used increasingly in recent years as an aid to clinical diagnosis and prognosis, but the literature contains few references to the exploitation of these laboratory tests in paediatrics. Following the development in these laboratories of assay procedures for glutamate-oxalacetate transaminase (GO-T), glutamate-pyruvate transaminase (GP-T), lactate dehydrogenas...