نتایج جستجو برای: nonomuraea
تعداد نتایج: 103 فیلتر نتایج به سال:
Culture extracts from the cave-derived actinomycete Nonomuraea specus were investigated, resulting in the discovery of a new S-bridged pyronaphthoquinone dimer and its monomeric progenitors designated hypogeamicins A-D (1-4). The structures were elucidated using NMR spectroscopy, and the relative stereochemistries of the pyrans were inferred using NOE and comparison to previously reported compo...
Lantibiotics are ribosomally synthesized, posttranslationally modified peptide antibiotics. The biosynthetic gene cluster for microbisporicin, a potent lantibiotic produced by the actinomycete Microbispora corallina containing chlorinated tryptophan and dihydroxyproline residues, was identified by genome scanning and isolated from an M. corallina cosmid library. Heterologous expression in Nonom...
Nonomuraea gerenzanensis ATCC 39727 produces the glycopeptide antibiotic A40926, which is natural precursor of semi-synthetic, last-resort drug dalbavancin. To reduce cost dalbavancin production, it mandatory to improve productivity producing strain. Here, we report that exposure N. wild-type population sub-inhibitory concentrations A40926 led isolation differently resistant phenotypes a divers...
The phylum Actinobacteria is one of the most ubiquitously present bacterial lineages on Earth. In the present study, we try to explore the diversity of cultivable rare Actinobacteria in Sigangli Cave, Yunnan, China by utilizing a combination of different sample pretreatments and under different culture conditions. Pretreating the samples under different conditions of heat, setting the isolation...
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