Drugs that act more promiscuously provide fewer routes for the emergence of resistant mutants. This benefit, however, often comes at the cost of serious off-target and dose-limiting toxicities. The classic example is the antifungal amphotericin B (AmB), which has evaded resistance for more than half a century. We report markedly less toxic amphotericins that nevertheless evade resistance. They ...

OBJECTIVE To investigate the long term effect of radioactive iodine on thyroid function and size in patients with non-toxic multinodular goitre. DESIGN Consecutive patients with multinodular non-toxic goitre selected for radioactive iodine treatment and followed for a minimum of 12 months (median 48 months) after an intended dose of 3.7 MBq/g thyroid tissue corrected to a 100% uptake of iodin...

IN 1932, Cecil Joll, in his book "Diseases of the Thyroid Gland" emphasised that "although respiratory symptoms due to tracheal compression and alteration of voice were common", dysphagia was a "decidedly rare feature of simple goitre". Since then there has been little documentation on the subject. The following is an account of the symptoms found in a series of patients undergoing surgery for ...

A 40-year-old female patient developed toxic shock syndrome following breast surgery. A toxin producing strain of Staphylococcus aureus was isolated from the post-operative wound. INTRODUCTION The term toxic shock syndrome (TSS) was first used in 1978 1 to describe a condition characterised by sudden onset of fever, shock, confusion, subcutaneous oedema, erythematous rash which desquamates in c...

Knowledge of the inverted "T" incision--used in plastic, oncologic and orthopedic surgery--has allowed its adaptation for the diagnostic assessment and therapeutical approach of acral, nodular lesions. The authors describe the use of this technique for the surgical approach of a patient with a plantar nodular lesion, further diagnosed as a calcified angioleiomyoma.

The leaves of Eupatorium semialatum were investigated for the occurrence of pyrrolizidine alkaloids. Although this type of alkaloids generally occurs in the Eupatorieae, only unusual non-toxic pyrrolizidines of the tussilagin type were identified. All compounds are methyl esters of the corresponding beta-amino acids.

The present opinions on the therapy with L-thyroxine (L-T4) of non-toxic multinodular, as well as of non-toxic thyroid nodules are rather divergent. This treatment is based on the suppression of TSH secretion from the pitu-

Paralysis in man and the domestic fowl caused by "ToCP" (tri-cresyl phosphate, tri-tolyl phosphate or TTP) is reviewed, and the search for a non-toxic plasticizer derived either from TTP or tri-xylenyl phosphate (tri-dimethylphenyl phosphate or TXP) is described. It had been previously shown that the ortho-tolyl esters are toxic but we found that their removal does not make the mixture non-toxi...