Quinine is the best studied drug for treating severe malaria in very young children. Quinine may be administered in pregnancy and, at therapeutic doses, malformations have not been reported. Some strains of quinine from Southeast Asia and South America have become resistant. Quinine is the treatment of choice for the drug-resistant severe Plasmodium falciparum. The antimalarial mechanism of qui...

BACKGROUND Malaria is a serious public health problem in sub-Saharan Africa and is a leading cause of morbidity and mortality. AIM To estimate the economic burden of malaria in rural households. SETTING The study was conducted in Gwanda district of Matabeleland South in Zimbabwe. A total of five malarious wards and all their households were selected for the study frame, out of which 80 hous...

Malaria is endemic in 91 countries. Maximum mortality is associated with Plasmodium falciparum malaria and more than 8,00,000 deaths occur in children less than five years of age1. P. falciparum usually presents with severe or complicated malaria, which presents as fever, chills, shock, hepatic failure, renal failure, cerebral malaria and malarial sepsis. It leads to 100% mortality if left untr...

CD163 is an acute-phase-regulated monocyte/macrophage membrane receptor expressed late in inflammation. It is involved in the haptoglobin-mediated removal of free hemoglobin from plasma, has been identified as a naturally soluble plasma glycoprotein with potential anti-inflammatory properties, and is possibly linked to an individual's haptoglobin phenotype. High levels of soluble CD163 (sCD163)...

Angioimmunoblastic T-cell lymphoma (AITL) is a rare and aggressive form of peripheral (PTCL). It can present with signs symptoms that have broad differentials, including fevers, night sweats, skin rashes. In this case report, we an interesting young male Nigerian descent recently treated malaria who presented such picture was complicated, due to inconclusive excisional biopsy for lymphoma. He l...

Possible pathophysiological, clinical and epidemiological interactions between human immunodeficiency virus (HIV) and tropical pathogens, especially malaria parasites, constitute a concern in tropical areas. Two decades of research have shown that HIV-related immunosuppression is correlated with increased malaria infection, burden, and treatment failure, and with complicated malaria, irrespecti...

OBJECTIVE Despite a substantial disease burden, little is known about the natural history of complicated falciparum malaria. Therefore, the present prospective study was undertaken to assess the clinical course, outcome, and resolution time of various complications of falciparum malaria. METHODS This prospective study has been conducted in a tertiary health care institution with high prevalen...

BACKGROUND & OBJECTIVES The increase in Plasmodium falciparum infections which are associated with severe and complicated malaria and drug resistance has made control of malaria a difficult task. Extensive genetic polymorphism in P. falciparum has been reported from several parts of the world which affects the efficacy of sub-unit vaccines. The knowledge of genotypes of the parasite in a geogra...

Introduction Malaria in very young children is a major therapeutic challenge in highly endemic areas where initial infection can occur in the first few months of life. Because active immunity has not begun to be established, infants are most at risk from falciparum malaria, and it has been estimated by the World Health Organisation that up to 1096 of all infant mortality in Africa is directly o...