This study evaluated the toxicokinetics of N-[(14)C]methylpyrrolidone ([(14)C]NMP) after intravenous administration (0.1, 1, 10, 100, and 500 mg/kg, in saline solution) or topical application (20 and 40 micro l/cm(2); 10 cm(2), neat) in haired male Sprague-Dawley rats. Whatever the dose, unchanged NMP was intensively distributed into the body with a volume of distribution of 69% of body weight....

While total physical activity decreases over the life course, sports and leisure-time physical activity (LTPA) have shown to increase after transition to retirement. This paper aimed to investigate whether this change in sports participation differs (1) between non-migrant persons (NMP) versus persons with a migrant background (PMB), and (2) by acculturation status. Data was drawn from 16 waves...

PURPOSE Difficulty exists in interpreting the significance of atypical urine cytology. This study was performed to assess the diagnostic utility of nuclear matrix protein-22 (NMP-22) testing when atypical cells are detected during urine cytology. MATERIALS AND METHODS Among patients whose urine cytology was reported as atypical between January 2004 and December 2009, a total of 275 who also u...

OBJECTIVES The aim of the present study was to compare a newly developed biodegradable polylactide/polyglycolide/N-methyl-2-pyrrolidone (PLGA/NMP) membrane with a standard resorbable collagen membrane (RCM) in combination with and without the use of a bone substitute material (deproteinized bovine bone mineral [DBBM]) looking at the proposed tenting effect and bone regeneration. MATERIALS AND...

Ultra-low delay sensitive applications can a‚ord delay only at the level of msec. An example of this application class are the Networked Music Performance (NMP) systems that describe a live music performance by geographically separate musicians over the Internet. Œe present work proposes a novel architecture for NMP systems, where the key-innovation is the close collaboration between the networ...

The use of statistical complexity metrics has yielded a number of successful methodologies to differentiate and identify signals from complex systems where the underlying dynamics cannot be calculated. The Mori-Zwanzig framework from statistical mechanics forms the basis for the generalized non-Markov parameter (NMP). The NMP has been used to successfully analyze signals in a diverse set of com...

Vertebrate skeletal muscles contain muscle fibers of several types, which can be broadly classified as slow or fast fibers, on the basis of differences in contraction speeds, metabolic activities, and motoneuron innervation. We have examined the potential roles of growth factors of members of the hedgehog and TGF-ß gene families in the formation of slow muscle fibers including muscle pioneer (M...

OBJECTIVES The sensitivity of voided urinary cytology has been reported as very low. In this study, we investigated the sensitivity and clinical utility of voided urinary cytology in the detection of various grades and stages of transitional cell carcinoma (TCC) of the bladder compared with the urinary nuclear matrix protein-22 (NMP-22) qualitative assay. METHODS From March 2004 to April 2006...

The development of improved preservation techniques and the reliable assessment of donor grafts are main fields of research in transplantation medicine. Normothermic machine perfusion (NMP) is a promising alternative to static cold storage of organs, maintaining physiological conditions during preservation. In combination with NMP, we introduce hyperspectral imaging (HSI) as a novel approach fo...