AlphaCPs comprise a subfamily of KH-domain-containing RNA-binding proteins with specificity for C-rich pyrimidine tracts. These proteins play pivotal roles in a broad spectrum of posttranscriptional events. The five major alphaCP isoforms are encoded by four dispersed loci. Each isoform contains three repeats of the RNA-binding KH domain (KH1, KH2, and KH3) but lacks other identifiable motifs. ...

In the majority of acute promyelocytic leukemia (APL) cases, translocons produce a promyelocytic leukemia protein-retinoic acid receptor α (PML-RARα) fusion gene. Studies have reported that neutrophil elastase (NE) cleaves bcr-1-derived PML-RAα in early myeloid cells, leaving only the nuclear localization signal (NLS) of PML attached to RARα. NLS-RARα promotes cell growth and inhibits different...

Nested-loop secondary linear doubly-fed machine (NLS-LDFM) is a novel evolved from rotary brushless induction machine, which has good application prospect in metro. In order to analyze the performance of NLS-LDFM, mechanism and action rules end effects are investigated this paper. Firstly, static dynamic analyzed aspect direct coupling, winding asymmetry transient current. Furthermore, based on...

The human RNA-editing enzyme adenosine deaminase acting on RNA (ADAR1) carries a unique nuclear localization signal (NLS) that overlaps one of its double-stranded RNA-binding domains (dsRBDs). This dsRBD-NLS is recognized by the nuclear import receptor transportin 1 (Trn1; also called karyopherin-β2) in an RNA-sensitive manner. Most Trn1 cargos bear a well-characterized proline-tyrosine-NLS, wh...

Activation of T lymphocytes by Ags or cytokines results in translocation of the transcription factors NF-kB, AP-1, NFAT, and STAT from the cytoplasm into the nucleus. The first step in the nuclear import process is recognition of a nuclear localization sequence (NLS) within the karyophilic protein by a cytoplasmic receptor such as the importin (karyopherin)-a subunit. The NLSs of NF-kB, AP-1, a...

We analyze self-focusing and singularity formation in the nonlinear Schrödinger equation (NLS) with high-order dispersion iψt±∆ψ+ |ψ|2σψ = 0, in the isotropic mixed-dispersion NLS iψt + ∆ψ + ǫ∆2ψ + |ψ|2σψ = 0, and in nonisotropic mixed-dispersion NLS equations which model propagation in fiber arrays.

In this short note, we present some decay estimates for nonlinear solutions of 3d quintic, cubic NLS, and 2d quintic NLS (nonlinear Schrödinger equations).

The critical nonlinear SchrSdinger equation (NLS) models the propagation of intense laser light ill Kerr media. This equation is derived from tile more conq)reheasive nonlinear Hehnholtz e(tuation (NLH) t)y employing the paraxial at)t)roximation and negle(:ting th(' backscattered waves. It is known that if the input power of tile laser beam (i.e., L2 norm of the ilfitial soh,ti(m) is sufficient...

UNLABELLED Our aim was to construct and characterize (111)In-nuclear translocation sequence (NLS)-7G3, an Auger electron-emitting radioimmunotherapeutic agent that preferentially recognizes the expression of CD123 (interleukin-3 receptor [IL-3R] α-subchain) in the absence of CD131 (IL-3R β-subchain) displayed by leukemia stem cells. METHODS Monoclonal antibody 7G3 was modified with 13-mer pep...