نتایج جستجو برای: nk1r

تعداد نتایج: 208  

2006
Maria-Simonetta Faussone-Pellegrini Maria-Giuliana Vannucchi

The tachykinin substance P (SP) acts on the gut muscle coat via its preferred receptor, neurokinin 1 (NK1r). In the mouse ileum, NK1r-immunoreactivity (NK1r-IR) was detected in neurons, in the interstitial cells of Cajal at the deep muscular plexus (ICC-DMP) and the myoid cells of the villi. SP-IR was detected in neurons and varicose nerve fibers, which were especially numerous at the DMP and c...

2014
Najma Baseer Abdullah S. Al-Baloushi Masahiko Watanabe Safa A.S. Shehab Andrew J. Todd

Fine myelinated (Aδ) nociceptors are responsible for fast, well-localised pain, but relatively little is known about their postsynaptic targets in the spinal cord, and therefore about their roles in the neuronal circuits that process nociceptive information. Here we show that transganglionically transported cholera toxin B subunit (CTb) labels a distinct set of afferents in lamina I that are li...

Journal: :Journal of neurology & neuromedicine 2016
Alejandra N Martinez Mario T Philipp

This review addresses the role that substance P (SP) and its preferred receptor neurokinin-1 (NK1R) play in neuroinflammation associated with select bacterial, viral, parasitic, and neurodegenerative diseases of the central nervous system. The SP/NK1R complex is a key player in the interaction between the immune and nervous systems. A common effect of this interaction is inflammation. For this ...

ژورنال: کومش 2018
بشاش, داود, رازانی, الهام, صفراوغلی آذر, آوا,

هدف: به دنبال معرفی مسیر پیام‌رسانی NK1R به عنوان یک مسیر کارسینوژنیک، مطالعات زیادی، فعالیت غیرطبیعی این مسیر را در بسیاری از بدخیمی‌های انسانی گزارش کرده‌اند. بر اساس اهمیت قابل توجه مسیر NK1R در پاتوژنز لوسمی لنفوبلاستیک حاد (Acute Lymphoblastic Leukemia) (ALL)، هدف این مطالعه بررسی تاثیر مهارکننده غیرپپتیدی و رقابتی ) NK1R  (Aprepitant، ا بر رده سلولی REH، مشتق شده از لوسمی لنفوبلاستیک حاد ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
Y Joy Yu Seksiri Arttamangkul Christopher J Evans John T Williams Mark von Zastrow

mu-Opioid receptors (MORs) are G-protein-coupled receptors (GPCRs) that mediate the physiological effects of endogenous opioid neuropeptides and opiate drugs such as morphine. MORs are coexpressed with neurokinin 1 receptors (NK1Rs) in several regions of the CNS that control opioid dependence and reward. NK1R activation affects opioid reward specifically, however, and the cellular basis for thi...

Journal: :Molecular Pain 2008
Chi-Kun Tong Edward J Kaftan Amy B MacDermott

NMDA receptors are important elements in pain signaling in the spinal cord dorsal horn. They are heterotetramers typically composed of two NR1 and two of four NR2 subunits: NR2A-2D. Mice lacking specific NR2 subunits show deficits in pain transmission yet subunit location in the spinal cord remains unclear. We have combined electrophysiological and pharmacological approaches to investigate the ...

Journal: :The Journal of clinical endocrinology and metabolism 2013
Brett D McKinnon Jakob Evers Nick A Bersinger Michael D Mueller

CONTEXT Endometriosis is characterized by the growth of ectopic endometrial tissue. Nerve fibers are frequently associated with ectopic lesions, and neurogenic inflammation may play a role in endometriosis. OBJECTIVE The purpose of this study was to determine the presence of tachykinin receptors in endometriotic lesions and the role of TNFα on their expression. DESIGN This study was an asse...

Journal: :Pain 2015
Tasuku Akiyama Tony Nguyen Eric Curtis Katsuko Nishida Jahnavi Devireddy Jeremy Delahanty Mirela Iodi Carstens Earl Carstens

We investigated roles for spinal neurons expressing the neurokinin-1 receptor (NK1R) and/or gastrin-releasing peptide receptor (GRPR) in a mouse model of ovalbumin (OVA)-induced chronic atopic dermatitis. Mice receiving repeated topical application of OVA exhibited atopic-like skin lesions and behavioral signs of chronic itch including spontaneous scratching, touch-evoked scratching (alloknesis...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2014
Fanyin Meng Sharon DeMorrow Julie Venter Gabriel Frampton Yuyan Han Heather Francis Holly Standeford Shanika Avila Kelly McDaniel Matthew McMillin Syeda Afroze Micheleine Guerrier Morgan Quezada Debolina Ray Lindsey Kennedy Laura Hargrove Shannon Glaser Gianfranco Alpini

Substance P (SP) promotes cholangiocyte growth during cholestasis by activating its receptor, NK1R. SP is a proteolytic product of tachykinin (Tac1) and is deactivated by membrane metalloendopeptidase (MME). This study aimed to evaluate the functional role of SP in the regulation of cholangiocarcinoma (CCA) growth. NK1R, Tac1, and MME expression and SP secretion were assessed in human CCA cells...

2016
Ashley J. Porter Katharine Pillidge S. Clare Stanford Jared W. Young

Mice lacking functional NK1 (substance P-preferring) receptors typically display excessive inattentiveness (omission errors) and impulsivity (premature responses) when compared with wildtypes in the 5-Choice Serial Reaction-Time Test (5-CSRTT). These abnormal behaviours are analogous to those seen in humans suffering from Attention Deficit Hyperactivity Disorder (ADHD). Here we used the 5-Choic...

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