نتایج جستجو برای: nitrosamines
تعداد نتایج: 1291 فیلتر نتایج به سال:
The formation of nitrosamines and reactions of the first and second phase of their biotransformations were reviewed.
Five cyclic nitrosamines, nitrosoazetidine, nitrosopyrrolidine, nitrosopiperidine, nitrosomorpholine, and dinitrosopiperazine, labeled with deuterium and tritium, were injected into rats and then the nucleic acids of the liver were examined for the presence of alkylated bases derived from the nitrosamines. A semiquantitative mass spectrometric method able to detect 25 ng of a base was used. No ...
Nitrosarnine contaminants in certain pesticide formulations, especially dinitroaniline and some acid herbicides, has been firmly established. These contaminants arise from either chemical synthesis, as with the dinitroanilines, or from nitrosation in the product due to nitrite, as with certain halobenzoic acid formulations. The nitrosamines are either simple nitrosodialkylamine compounds or the...
BACKGROUND Multiple N-nitroso compounds have been observed in animal studies to be both mutagenic and teratogenic. Human exposure to N-nitroso compounds and their precursors, nitrates and nitrites, can occur through exogenous sources, such as diet, drinking water, occupation, or environmental exposures, and through endogenous exposures resulting from the formation of N-nitroso compounds in the ...
OBJECTIVES To examine if the occurrence of different cancers was increased among rubber workers, as the highest known exposures of humans to nitrosamines have occurred in the rubber industry. METHODS A cohort of 8933 rubber workers (hired after 1 January 1950, still active or retired on 1 January 1981 and employed for at least 1 year in one of five study factories) was followed up for mortali...
For decades, regulators have grappled with different approaches to address the issue of control impurities. Safety-based limits, such as permissible daily exposure (PDE), acceptable intake (AI), threshold toxicological concern (TTC) and less than lifetime limits (LTL) all been used. many years these safety-based recognized virtually safe doses (VSDs). Recently, however, regulatory agencies are ...
چکیده ندارد.
BACKGROUND The evidence about nitrosamines and heme iron intake and cancer risk is limited, despite the biologic plausibility of the hypothesis that these factors might increase cancer risk. We investigated the association between dietary nitrosamines and heme iron and the risk of prostate cancer among participants of European Prospective Investigation into Cancer and Nutrition (EPIC). METHOD...
The presence of mutagenic and carcinogenic nitrosamines in groundwater is of great concern. In this study, eight nitrosamines including N-nitrosodimethylamine (NDMA), N-nitrosodiethylamine (NDEA), N-nitrosomethylethylamine (NMEA), N-nitrosopyrrolidine (NPYR), N-nitrosomorpholine (NMOR), N-nitrosopiperidine (NPIP), N-nitrosodi-n-propylamine (NDPA), and N-nitrosodi-n-butylamine (NDBA) and corresp...
Using a method for nitrosamine analysis that gives high recovery values and that is free from artifactual synthesis of nitrosamines, we have shown that human feces do not contain volatile nitrosamines (detection limit, 0.1 to 0.5 /ng/kg). We also showed that nitrosation reactions are not catalyzed by fecal organisms. Following a 2-day anaerobic incubation of feces with either a secondary aminé...
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